Answers that end in a number.
What these drugs do, what dose you end up on, and what it costs when you get there. Every clinical fact is quoted from the label with its source; every price is read off the seller’s own page and dated.
123 guides · 27 programs tracked · cheapest today $41/mo, checked November 2026
Cheapest GLP-1 right now$41/mo at Wellmedr, billed monthly. Checked 12 Nov 2026.
$41/mo at Wellmedr on Wellmedr’s site ↗
Written by Julian Caraulani. Clinical statements are quoted from labels, the FDA and trials; guides marked reviewed were read by Dr. A. Goher, MD.
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Latest · Buying safelyTirzepatide online: how to get a prescription, the versions sold, and what to check before you buyYou can get tirzepatide online, but only with a prescription from a licensed clinician. It comes as Eli Lilly's Zepbound (FDA approved for weight loss and sleep apnea), as Lilly's Mounjaro (approved for type 2 diabetes), or as a compounded injection made by a pharmacy, which is not FDA approved. Compounded tirzepatide starts at $71 a month on our board.Recently checked
Doses and injectingGLP-1 before and after (2026)In the two big obesity trials, the average after was 14.9% of body weight lost on semaglutide at 68 weeks and 15.0% to 20.9% on tirzepatide at 72 weeks, against 2.4% and 3.1% on placebo. The average hides a spread: about half of people on semaglutide passed 15%, and about one in seven did not reach 5%.8 min · checked November 2026Buying safelyGLP-1 Supplements (2026)No GLP-1 supplement contains a GLP-1 drug. Products sold as GLP-1 boosters, gummies or natural GLP-1 are dietary supplements, usually built on berberine, fiber or probiotics, and FDA does not approve them before they are sold. In trials, berberine averaged about 2 lb (0.88 kg) more weight loss than control across 23 studies; semaglutide, the drug in Wegovy, averaged about 28 lb (12.7 kg) more than placebo at 68 weeks. A real GLP-1 needs a prescription, and the cheapest cash program on our board is $41 a month.8 min · checked November 2026
The drugsHow long GLP-1 stays in your system (2026)It depends on the drug, and for the weekly shots the answer is weeks, not days. The FDA label for Ozempic says semaglutide stays in the blood for about 5 weeks after the last dose; Wegovy's label says 5 to 7 weeks. Tirzepatide (Zepbound, Mounjaro) has a half-life of about 5 to 6 days, so it is mostly gone in about a month. Foundayo, the daily pill, clears in about a week. Below: each label's figures and what they mean for pregnancy.6 min · checked November 2026What it costs
Prices, coupons, insurance and the arithmetic of paying cash, checked against the seller's own page.
What it costsCostco GLP-1 Price 2026Costco has no GLP-1 price of its own. Its pharmacy sells Wegovy and Ozempic at Novo Nordisk's self-pay price, which launched there at $499 in October 2025 and is now $349 a month for most pen doses at Novo's own pharmacy. The 2024 Costco and Sesame weight-loss bundle no longer appears on Sesame's Costco page. CVS, Walgreens and Walmart run the same maker prices: $149 for the Wegovy pill's starting dose, $299 for a starting Zepbound vial.16 min · checked November 2026
What it costsWegovy Pill Cost (2026)The Wegovy pill is a once-a-day semaglutide tablet for weight loss, FDA-approved and on sale since January 2026. Paying cash, Novo Nordisk charges $149 a month at the starting dose, $199 at the second step and $299 at the higher doses, against $349 a month for the Wegovy pen. In its main trial, people on the full-strength tablet lost 13.6% of their body weight on average over 64 weeks.6 min · checked November 2026
What it costsWegovy coupon (2026)Novo's Wegovy savings offer advertises as little as $25 a month and caps the saving at $100 a month, or $300 on a 3-month fill. That cap decides your number: a $110 copay becomes $25, a $400 copay becomes $300. Medicare, Medicaid, VA and TRICARE are excluded, so there the $50 Medicare GLP-1 Bridge is the route. With no insurance the card does nothing; Novo's cash pen is $199 for a new patient's first two fills, then $349.9 min · checked November 2026Side effects
What these drugs do to your body, what the label says, and what to do about it.
Side effectsOzempic teeth (2026)No GLP-1 label lists tooth damage as a side effect, and no prospective study has measured teeth in people taking one. What dentists describe as Ozempic teeth runs through side effects the labels do list: vomiting and reflux that bathe teeth in stomach acid, and dry mouth, which raises the risk of decay. A 2026 dental review calls that risk plausible but unquantified. Rinsing after vomiting, fluoride and water are the ADA's answers.8 min · checked October 2026Side effectsGLP-1 before surgery (2026)Most people can keep taking a GLP-1 before elective surgery, according to 2024 guidance from five medical societies including the American Society of Anesthesiologists, which replaced its 2023 advice to hold a weekly shot for a week. People at the highest risk (early in dose increases, on a high dose, or with nausea, vomiting or bloating) may be asked to follow a liquid diet for 24 hours, have a stomach ultrasound or wait. Every label says to tell the team you take it.9 min · checked October 2026Side effectsGLP-1 and birth control (2026)Tirzepatide (Zepbound, Mounjaro) and orforglipron (Foundayo) can make the birth control pill less reliable, so their labels say to switch to a non-oral method or add a condom for 4 weeks (30 days for Foundayo) after starting and after every dose increase. Semaglutide (Ozempic, Wegovy, Rybelsus) carries no such rule: its label studies showed no clinically significant change in pill hormones. The patch, ring, shot, implant and IUD are not affected by any of them.10 min · checked October 2026Doses and injecting
The manufacturer's own ladder, week by week, and what each step costs.
Doses and injectingGLP-1 before and after (2026)In the two big obesity trials, the average after was 14.9% of body weight lost on semaglutide at 68 weeks and 15.0% to 20.9% on tirzepatide at 72 weeks, against 2.4% and 3.1% on placebo. The average hides a spread: about half of people on semaglutide passed 15%, and about one in seven did not reach 5%.8 min · checked November 2026Doses and injectingOzempic 6 week results (2026)At week 6 on Ozempic you are on your second 0.5 mg dose, after four starter weeks at 0.25 mg, and the label says each dose takes 4 to 5 weeks to reach steady levels. No trial we read reports a week-6 weight figure. The nearest published points: 5.0 kg average loss after 12 weeks in a semaglutide appetite trial, and 5.9% at three months in a Mayo Clinic cohort on Wegovy doses.8 min · checked October 2026
Doses and injectingMicrodosing GLP-1 (2026)Microdosing a GLP-1 does not save money at a compounded seller: none of the compounded programs we track charges less for a smaller dose. Microdosing is not a medical term, and no dose below the label's starting dose has been studied for this. The one microdosing product on our board costs more a month than full-dose compounded tirzepatide at the cheapest seller we track. Where dose really moves the price is the brands; the provider table, per-mg costs and live numbers are below.13 min · checked October 2026The drugs
What each one is, who it is approved for, and how it differs from the one next to it.
The drugsHow long GLP-1 stays in your system (2026)It depends on the drug, and for the weekly shots the answer is weeks, not days. The FDA label for Ozempic says semaglutide stays in the blood for about 5 weeks after the last dose; Wegovy's label says 5 to 7 weeks. Tirzepatide (Zepbound, Mounjaro) has a half-life of about 5 to 6 days, so it is mostly gone in about a month. Foundayo, the daily pill, clears in about a week. Below: each label's figures and what they mean for pregnancy.6 min · checked November 2026The drugsRybelsus Discontinued?Yes, in practice: Novo Nordisk is phasing Rybelsus out in the US and replacing it with the Ozempic pill, the same drug (semaglutide) in a new tablet at lower milligram strengths. It was not pulled for safety and is still FDA-approved. Novo told Illinois Medicaid it stopped shipping Rybelsus to wholesalers in May 2026, so pharmacy stock is running down. Moving over takes a new prescription, and your prescriber picks the matching strength.6 min · checked November 2026The drugsRybelsus for Weight Loss (2026)Rybelsus can lower weight a little, but it is approved for type 2 diabetes, not for weight loss. In its main diabetes trial, people on the highest Rybelsus strength lost about 5 lb (2.3 kg) more than placebo over 26 weeks. The 13 to 15 percent weight losses in the news came from stronger semaglutide tablets made for weight loss. The tablet labelled for weight is the Wegovy pill.6 min · checked November 2026Buying safely
How to tell a licensed program from a bad one before you hand over a card.
Buying safelyTirzepatide online (2026)You can get tirzepatide online, but only with a prescription from a licensed clinician. It comes as Eli Lilly's Zepbound (FDA approved for weight loss and sleep apnea), as Lilly's Mounjaro (approved for type 2 diabetes), or as a compounded injection made by a pharmacy, which is not FDA approved. Compounded tirzepatide starts at $71 a month on our board.9 min · checked November 2026Buying safelyGLP-1 Supplements (2026)No GLP-1 supplement contains a GLP-1 drug. Products sold as GLP-1 boosters, gummies or natural GLP-1 are dietary supplements, usually built on berberine, fiber or probiotics, and FDA does not approve them before they are sold. In trials, berberine averaged about 2 lb (0.88 kg) more weight loss than control across 23 studies; semaglutide, the drug in Wegovy, averaged about 28 lb (12.7 kg) more than placebo at 68 weeks. A real GLP-1 needs a prescription, and the cheapest cash program on our board is $41 a month.8 min · checked November 2026Buying safelyZepbound KwikPen (2026)The Zepbound KwikPen is one pen that holds a month of Zepbound: four fixed weekly doses of the same strength. You attach a new pen needle each week (needles are not in the box), prime it, then turn the dose knob all the way and inject. It is the only Zepbound the Medicare GLP-1 Bridge covers, at a $50 copay per month's supply. Paying cash, Lilly's self-pay prices by strength and today's board prices are below.8 min · checked November 2026News
Price moves from our weekly checks, and maker and FDA changes, each dated and sourced.
Why any of this is here
The board is the product. These exist so you know what you are buying.
We re-check 27 programs weekly. The board always shows today’s cheapest.