Price your own schedule
Pick the medication, how you pay, and the dose your prescriber has you stay on. The table shows the dose on each monthly fill at the label’s fastest pace and what that fill costs.
First 12 fills, Zepbound
$5,188
LillyDirect's self-pay prices, on the label's fastest schedule to 15 mg. From 7.5 mg this uses the maker's purchase offer, which holds only while each refill is within 45 days of the last; at the regular price the top dose is $699 a month.
Maker prices read Oct 3
Same molecule, compounded (not FDA-approved): $2,004 for 12 fills at TMates, on a 12-month plan.
Check price on TMates's site| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 2.5 mg | $299 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 5 mgdose steps up | $399 |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 7.5 mgdose steps up | $449 |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 10 mgdose steps up | $449 |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 12.5 mgdose steps up | $449 |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 15 mgdose steps up | $449 |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 15 mg | $449 |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 15 mg | $449 |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 15 mg | $449 |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 15 mg | $449 |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 15 mg | $449 |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 15 mg | $449 |
The label’s fastest schedule: four weeks per dose. The labels set four weeks as the minimum, so a slower climb keeps you on the cheaper starting doses longer. Your prescriber sets your dose. A fill here is four weekly doses, billed monthly; a calendar year holds about 13.
Zepbound titration schedule and cost
Lilly's self-pay price climbs with the dose to 7.5 mg on the KwikPen offer (to 10 mg at the regular price), then stays flat to 15 mg. On the fastest schedule to 15 mg the first 12 fills cost $5,188. Prices read Oct 3. From 7.5 mg this uses the maker's purchase offer, which holds only while each refill is within 45 days of the last; at the regular price the top dose is $699 a month.
| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 2.5 mg | $299 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 5 mg | $399 |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 7.5 mg | $449 |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 10 mg | $449 |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 12.5 mg | $449 |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 15 mg | $449 |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 15 mg | $449 |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 15 mg | $449 |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 15 mg | $449 |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 15 mg | $449 |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 15 mg | $449 |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 15 mg | $449 |
| First 12 fills | $5,188 | ||
Wegovy titration schedule and cost
NovoCare Pharmacy charges a new patient $199 for each of the first two fills, then $349 a month at every dose from 0.25 to 2.4 mg, so the climb itself costs nothing extra. First 12 fills: $3,888. Prices read Oct 3.
| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 0.25 mg | $199 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 0.5 mg | $199 |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 1 mg | $349 |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 1.7 mg | $349 |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 2.4 mg | $349 |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 2.4 mg | $349 |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 2.4 mg | $349 |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 2.4 mg | $349 |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 2.4 mg | $349 |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 2.4 mg | $349 |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 2.4 mg | $349 |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 2.4 mg | $349 |
| First 12 fills | $3,888 | ||
Ozempic titration schedule and cost
Ozempic is approved for type 2 diabetes, not weight loss. On its label's fastest schedule to 2 mg, the first 12 fills at NovoCare Pharmacy's self-pay prices cost $5,238.
| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 0.25 mg | $199 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 0.5 mg | $199 |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 1 mg | $349 |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 2 mg | $499 |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 2 mg | $499 |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 2 mg | $499 |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 2 mg | $499 |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 2 mg | $499 |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 2 mg | $499 |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 2 mg | $499 |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 2 mg | $499 |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 2 mg | $499 |
| First 12 fills | $5,238 | ||
Mounjaro titration schedule
Mounjaro is approved for type 2 diabetes, not weight loss. Lilly publishes its self-pay price only as “starting at $499/month”, so the higher doses show as not published rather than guessed. The same molecule for weight loss is Zepbound, priced above.
| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 2.5 mg | $499 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 5 mg | not published |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 7.5 mg | not published |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 10 mg | not published |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 12.5 mg | not published |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 15 mg | not published |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 15 mg | not published |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 15 mg | not published |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 15 mg | not published |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 15 mg | not published |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 15 mg | not published |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 15 mg | not published |
| First 12 fills | not computable | ||
Compounded tirzepatide and semaglutide: a year’s cost
Compounded GLP-1s have no FDA label and are not FDA-approved; the schedule shown is the matching brand’s label schedule, as a reference. Most programs publish one entry price, not a price per dose, so only programs that price every dose on the schedule are counted here.
Compounded tirzepatide
$2,004 for 12 fills at TMates, on a 12-month plan, to 15 mg.
| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 2.5 mg | $167 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 5 mg | $167 |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 7.5 mg | $167 |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 10 mg | $167 |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 12.5 mg | $167 |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 15 mg | $167 |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 15 mg | $167 |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 15 mg | $167 |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 15 mg | $167 |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 15 mg | $167 |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 15 mg | $167 |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 15 mg | $167 |
| First 12 fills | $2,004 | ||
Compounded semaglutide
$1,896 for 12 fills at TMates, on a 12-month plan, to 2.4 mg.
| Fill | Weeks | Dose | Price |
|---|---|---|---|
| 1Weeks 1 to 4 | Weeks 1 to 4 | 0.25 mg | $158 |
| 2Weeks 5 to 8 | Weeks 5 to 8 | 0.5 mg | $158 |
| 3Weeks 9 to 12 | Weeks 9 to 12 | 1 mg | $158 |
| 4Weeks 13 to 16 | Weeks 13 to 16 | 1.7 mg | $158 |
| 5Weeks 17 to 20 | Weeks 17 to 20 | 2.4 mg | $158 |
| 6Weeks 21 to 24 | Weeks 21 to 24 | 2.4 mg | $158 |
| 7Weeks 25 to 28 | Weeks 25 to 28 | 2.4 mg | $158 |
| 8Weeks 29 to 32 | Weeks 29 to 32 | 2.4 mg | $158 |
| 9Weeks 33 to 36 | Weeks 33 to 36 | 2.4 mg | $158 |
| 10Weeks 37 to 40 | Weeks 37 to 40 | 2.4 mg | $158 |
| 11Weeks 41 to 44 | Weeks 41 to 44 | 2.4 mg | $158 |
| 12Weeks 45 to 48 | Weeks 45 to 48 | 2.4 mg | $158 |
| First 12 fills | $1,896 | ||
Every compounded program, cheapest first: tirzepatide and semaglutide. Units for your vial: dosing calculator.
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Titration schedule: common questions
What is the Zepbound titration schedule?
On the Zepbound label: 2.5 mg once weekly for 4 weeks, then 5 mg, and the dose may rise in 2.5 mg steps after at least 4 weeks on each dose. The maintenance dose is 5, 10 or 15 mg, and 15 mg is the maximum.
What is the Wegovy titration schedule?
On the Wegovy label: 0.25 mg weekly for weeks 1 to 4, 0.5 mg for weeks 5 to 8, 1 mg for weeks 9 to 12, 1.7 mg for weeks 13 to 16, then a maintenance dose of 1.7 or 2.4 mg (2.4 mg recommended).
How much does the first year of Zepbound cost without insurance?
At Lilly's self-pay prices on the fastest label schedule to 15 mg: 2.5 mg $299, 5 mg $399, 7.5 mg $449, 10 mg $449, then $449 a month, $5,188 for the first 12 fills. Prices read Oct 3.
How much does the first year of Wegovy cost without insurance?
At NovoCare Pharmacy's self-pay prices: $199 for each of a new patient's first two fills, then $349 a month at every dose from 0.25 to 2.4 mg, $3,888 for the first 12 fills. Prices read Oct 3.
Does a slower titration cost less?
On Zepbound, yes: Lilly's self-pay price rises with the dose, so every extra month on a lower dose is cheaper. On Wegovy, no: after the first two fills NovoCare charges the same price at every dose from 0.25 to 2.4 mg. The labels set four weeks as the minimum time on each dose; your prescriber sets the pace.
Why is Mounjaro's year total not shown?
Lilly publishes Mounjaro's self-pay price only as "starting at $499/month" and no price for the higher doses, so a year total would be a guess. Mounjaro is approved for type 2 diabetes, not for weight loss; Zepbound is the same molecule approved for weight loss.
Where these facts come from
We track prices. Every clinical and manufacturer claim about titration schedules and self-pay prices on this page is quoted here in its source’s own words, with the date we read it. We do not write medical guidance and we do not tell anyone what dose to take.
8 sources · read Oct 3
- 01read Oct 2
The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks. The 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage. ... After 4 weeks, increase the dosage to 5 mg injected subcutaneously once weekly. The dosage may be increased in 2.5 mg increments, after at least 4 weeks on the current dose ... The recommended maintenance dosage is 5 mg, 10 mg, or 15 mg, injected subcutaneously once weekly. ... The maximum dosage of ZEPBOUND for all indications is 15 mg injected subcutaneously once weekly.
Zepbound prescribing information, dosage - 02read Oct 2
Table 1. Recommended Starting Dosage and Dosage Escalation: Starting Dosage, weeks 1 through 4, 0.25 mg · Dosage Escalation, weeks 5 through 8, 0.5 mg · weeks 9 through 12, 1 mg · weeks 13 through 16, 1.7 mg · Maintenance Dosage, 17 and onward. ... The maintenance dosage of WEGOVY for weight reduction in adults is either 1.7 mg or 2.4 mg (recommended) injected subcutaneously once weekly. ... If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.
Wegovy prescribing information, Table 1 and maintenance dosage - 03read Oct 3
The recommended starting dosage is 2.5 mg injected subcutaneously once weekly. ... If additional glycemic control is needed, increase the dosage in 2.5 mg increments after at least 4 weeks on the current dose. ... Adults: 15 mg subcutaneously once weekly.
Mounjaro prescribing information, dosage and administration - 04read Oct 3
Start at 0.25 mg once weekly. After 4 weeks, increase the dosage to 0.5 mg once weekly. ... If additional glycemic control is needed, increase the dosage to 1 mg once weekly after at least 4 weeks on the 0.5 mg dose. ... If additional glycemic control is needed, increase the dosage to 2 mg once weekly after at least 4 weeks on the 1 mg dosage.
Ozempic prescribing information, dosage and administration - 05read Oct 3
The list price of Zepbound is $499 - $1,086.37 per fill, but the amount you pay will largely depend on your prescription drug insurance plan. ... Available through Zepbound self-pay, Zepbound is offered as a 4‑count single‑dose vial (0.5mL) and a single‑patient‑use KwikPen (2.4mL, 0.6mL/dose) in doses of 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg, with direct‑to‑patient pricing of $299, $399, $499, $699, $699 and $699 respectively. ... If you have commercial drug insurance with coverage for Zepbound, you may be eligible to pay as low as $25 for a one- or three-month supply Zepbound single-dose pens.
Eli Lilly, Zepbound cost information - 06read Oct 2
Pay as little as $25, subject to a maximum savings of $100/month. ... Patients new to the Wegovy® Savings Offer or NovoCare® Pharmacy pay $199 for each month of 0.25 mg & 0.5 mg. Offer for 2 monthly fills through December 31, 2026, then $349 per month for Wegovy® 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg, and $399 per month for Wegovy® HD (semaglutide) injection 7.2 mg. ... Government-insured patients may use this program if they self pay and process outside of their insurance. ... The money spent and discounts on your prescription will not count toward your deductible or out-of-pocket requirements
NovoCare, Wegovy savings offer and self-pay pricing - 07read Oct 2
Pay as little as $25, subject to a maximum savings of $100/month. Eligibility and restrictions apply. Government beneficiaries excluded. ... Patients new to the Ozempic® Savings Offer or NovoCare® Pharmacy pay $199 for each month of 0.25 mg and 0.5 mg. Offer for 2 monthly fills through December 31, 2026, then $349 per month for Ozempic® 0.25 mg, 0.5 mg, or 1 mg, and $499/month for Ozempic® 2 mg. ... Patients who use this savings offer and are enrolled in government, state, or federally-funded medical or prescription benefit programs are able to pay the self-pay price for their prescription.
NovoCare, Ozempic savings offer and self-pay pricing - 08read Oct 2
Self-pay price: Starting at $499/month* ... * For self-pay. Prescription required. Terms apply. Additional taxes and fees may apply.
LillyDirect, Mounjaro self-pay