Read this before you draw a dose

The FDA has received reports of people hospitalized after measuring compounded semaglutide wrongly. Your dose comes from your prescriber and your vial’s strength from your pharmacy label. If a number here does not match your instructions, follow your instructions and ask your pharmacist. Syringes below are drawn as U-100 syringes: 50 units (0.5 mL) for semaglutide, 100 units (1 mL) for tirzepatide.

Convert any dose at your own vial strength

Draw up

10 units

on a U-100 insulin syringe (100 units = 1 mL)

Volume

0.1 mL

0.25 mg ÷ 2.5 mg/mL

Arithmetic only, not medical advice. Your dose is set by your prescriber and the concentration is whatever your pharmacy printed on the label; if the result does not match the instructions you were given, ask your pharmacist before you inject.

Want the week-by-week ladder and what each step costs? Read the semaglutide dose ladder or the tirzepatide dosage chart.

Semaglutide dosage chart, in units

The weekly schedule from the Wegovy label, with each dose converted to U-100 syringe units at the two vial strengths named in each column. Use the strength printed on your own vial.

WhenDoseVial 2.5 mg/mLVial 5 mg/mL
Weeks 1 to 40.25 mg10units (0.1 mL)5units (0.05 mL)
Weeks 5 to 80.5 mg20units (0.2 mL)10units (0.1 mL)
Weeks 9 to 121 mg40units (0.4 mL)20units (0.2 mL)
Weeks 13 to 161.7 mg68units (0.68 mL)34units (0.34 mL)
Week 17 on2.4 mgmaintenance: 1.7 or 2.4 mg96units (0.96 mL)48units (0.48 mL)

0.25 mg at 5 mg/mL

5 units

01020304050

0.5 mg at 5 mg/mL

10 units

01020304050

1 mg at 5 mg/mL

20 units

01020304050

1.7 mg at 5 mg/mL

34 units

01020304050

2.4 mg at 5 mg/mL

48 units

01020304050

Tirzepatide dosage chart, in units

The weekly schedule from the Zepbound label, with each dose converted to U-100 syringe units at the two vial strengths named in each column. Use the strength printed on your own vial.

WhenDoseVial 10 mg/mLVial 20 mg/mL
Weeks 1 to 42.5 mgstarting dose only25units (0.25 mL)12.5units (0.125 mL)
Weeks 5 to 85 mg50units (0.5 mL)25units (0.25 mL)
After 4+ weeks7.5 mg75units (0.75 mL)37.5units (0.375 mL)
After 4+ weeks10 mg100units (1 mL)50units (0.5 mL)
After 4+ weeks12.5 mg125units (1.25 mL)62.5units (0.625 mL)
After 4+ weeks15 mgmaximum150units (1.5 mL)75units (0.75 mL)

2.5 mg at 20 mg/mL

12.5 units

0102030405060708090100

5 mg at 20 mg/mL

25 units

0102030405060708090100

7.5 mg at 20 mg/mL

37.5 units

0102030405060708090100

10 mg at 20 mg/mL

50 units

0102030405060708090100

12.5 mg at 20 mg/mL

62.5 units

0102030405060708090100

15 mg at 20 mg/mL

75 units

0102030405060708090100

What one dose costs

The cheapest compounded injection programs we track, all-in monthly price divided by four weekly doses. Most of these programs publish one monthly price rather than a price per dose, so ask whether yours rises as you move up the schedule.

Compounded semaglutide

ProgramPer monthPer weekly dose
SnagRxmonthly$69$17.25
Embody12-month prepay$69$17.25
CoreAge Rxmonthly$99$24.75
Trimi12-month prepay$99$24.75
bmiMD12-month prepay$119$29.75

Compounded tirzepatide

ProgramPer monthPer weekly dose
SnagRxmonthly$119$29.75
Embody12-month prepay$119$29.75
Trimi12-month prepay$125$31.25
CoreAge Rxmonthly$149$37.25
TMates12-month prepay$167$41.75

Program links pay us a commission. The order is the all-in monthly price, never what anyone pays us. How we earn.

Dosage chart: common questions

How many units is 0.25 mg of semaglutide?

10 units on a U-100 syringe from a 2.5 mg/mL vial, or 5 units from a 5 mg/mL vial. The strength is on your pharmacy label; use that one.

How many units is 2.5 mg of tirzepatide?

25 units from a 10 mg/mL vial, 12.5 units from a 20 mg/mL vial.

How do I convert mg to units?

Divide your dose in mg by the vial concentration in mg per mL to get mL, then multiply by 100 to get units on a U-100 insulin syringe. Example: 0.5 mg ÷ 2.5 mg/mL = 0.2 mL = 20 units.

What is the semaglutide dosing schedule?

On the Wegovy label: 0.25 mg weekly for weeks 1 to 4, 0.5 mg for weeks 5 to 8, 1 mg for weeks 9 to 12, 1.7 mg for weeks 13 to 16, then a maintenance dose of 1.7 or 2.4 mg. Compounded semaglutide is dosed by your prescriber.

What is the tirzepatide dosing schedule?

On the Zepbound label: 2.5 mg weekly for 4 weeks, then 5 mg, rising in 2.5 mg steps after at least 4 weeks on each dose, to a maintenance dose of 5, 10 or 15 mg. 15 mg is the maximum.

How much does one dose of compounded semaglutide cost?

At the cheapest program we track, SnagRx, $17.25 per weekly dose: $69 a month all-in divided by four weekly injections.

Where these facts come from

We track prices. Every clinical and manufacturer claim about semaglutide and tirzepatide dosing on this page is quoted here in its source’s own words, with the date we read it. We do not write medical guidance and we do not tell anyone what dose to take.

3 sources · read Oct 2

  1. 01read Oct 2
    Table 1. Recommended Starting Dosage and Dosage Escalation: Starting Dosage, weeks 1 through 4, 0.25 mg · Dosage Escalation, weeks 5 through 8, 0.5 mg · weeks 9 through 12, 1 mg · weeks 13 through 16, 1.7 mg · Maintenance Dosage, 17 and onward. ... The maintenance dosage of WEGOVY for weight reduction in adults is either 1.7 mg or 2.4 mg (recommended) injected subcutaneously once weekly. ... If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.
    Wegovy prescribing information, Table 1 and maintenance dosage
  2. 02read Oct 2
    The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks. The 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage. ... After 4 weeks, increase the dosage to 5 mg injected subcutaneously once weekly. The dosage may be increased in 2.5 mg increments, after at least 4 weeks on the current dose ... The recommended maintenance dosage is 5 mg, 10 mg, or 15 mg, injected subcutaneously once weekly. ... The maximum dosage of ZEPBOUND for all indications is 15 mg injected subcutaneously once weekly.
    Zepbound prescribing information, dosage
  3. 03read Oct 2
    FDA received multiple reports of adverse events, some requiring hospitalization, that may be related to dosing errors associated with compounded injectable semaglutide products. These dosing errors resulted from patients measuring and self-administering incorrect doses of the drug, and in some cases, health care professionals miscalculating doses of the drug. ... The agency also encourages patients to talk with their health care provider or compounder about how to measure and administer the intended dose of compounded semaglutide or tirzepatide.
    FDA, concerns with unapproved GLP-1 drugs used for weight loss

Paying per vial? Check what a dose costs elsewhere.

One email when compounded semaglutide or tirzepatide gets cheaper.