GLP-1 TV · Patient story · views checked Oct 2026
Zepbound Week 1 Results | GLP-1 Weight Loss Journey, Symptoms, & New Measurements
Our summary
In this video, Enid Sabel reviews her first week on Zepbound after her first shot on July 31st and shows her second injection on camera. She says she took a protein shake before each shot and let the pen sit out for 30 to 40 minutes beforehand. According to her, she felt fine for about 10 hours after the first dose, then developed nausea in the evening. Nausea and reflux were strongest over the first two to three days, along with strong thirst, reduced appetite and a deeper sleep than usual. She also mentions tiredness, muscle aches in her legs and back, and occasional lightheadedness, and says she is unsure whether the aches come from the shot or from stress. Her cravings, including for sweets, returned around days four and five.
One person's experience, in their words. Not medical advice.
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What else the video covers
She then repeats her measurements. She says her weight went from 177.8 to 175.8 pounds, and she reports changes at the bust, hips, waist and arms compared with her starting numbers. Her waist went from 36 and a half inches to 36, her bust from 40 and a half to 39, and each arm from 16 to 14 and a half. She says she did not work out during the week and plans to add exercise, more water and more protein in week two.
She describes the second injection in her right thigh, saying she felt only a small prick and no burning this time. She also talks about looser pants, wanting to return to wearing a faja, and says she discussed the medication with her doctor, who will check in again in three months. These are her personal experiences, not medical advice.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 2:00 She says nausea began about 10 hours after her first dose and was strongest over the first two to three days, with reflux and heavy thirst.
- 5:00 She reports reduced appetite for roughly the first four days, with cravings returning later in the week.
- 7:50 She mentions deeper sleep, tiredness, muscle aches and some lightheadedness, and is unsure which come from the shot.
- 11:00 She demonstrates her second injection in the thigh and says it felt like a small prick without the burning she noticed the week before.
- 13:00 She reports waist, bust, hip, thigh and arm measurements that were mostly smaller than her starting numbers.
- 15:44 She says her weight dropped from 177.8 to 175.8 pounds and plans to add workouts and more water in week two.
Key moments
From the creator's own chapters. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Medication
- Zepbound
- Point in the journey
- Week 1
- Side effects mentioned
- nausea, fatigue and heartburn or reflux
- Who is speaking
- Patient
Questions this video answers
What side effects did she have in the first week of Zepbound?
She reports nausea starting about 10 hours after the first shot, reflux, strong thirst, tiredness, muscle aches and occasional lightheadedness. She says the nausea was worst in the first two to three days.
How much weight did she lose in week one on Zepbound?
She says she went from 177.8 to 175.8 pounds, a loss of 2 pounds. She also reports smaller measurements at several points, including her bust and arms.
Did Zepbound reduce her appetite in the first week?
She says it did not remove her hunger completely but limited how much she ate, mainly in the first four days. She reports cravings, including for sugar, coming back later in the week.
What did the second Zepbound injection feel like for her?
She says she felt only a small prick in her right thigh and did not feel the burning she noticed during the first injection. She describes holding the pen on the skin for 10 seconds.
Videos on the same question
The closest videos in the library by what is said in them, not by title.
3-Month Zepbound Results (Week 12 Update) | GLP-1 Weight Loss Journey, Side Effects & Before + AfterIn this week 12 update, the creator says she is three months into Zepbound, which she started on July 31st, 2025, and has no regrets.
Zepbound Journey Week 1-4: My Experiences and Thoughts #zepbound #glp1In this video, the creator looks back at her first month on Zepbound, a GLP-1 medication she says is used for weight loss.
7 Month Zepbound Update | Week 28, Shot #29, Final Results & Starting MaintenanceIn this video, Enid Sabel marks the end of the weight loss phase of her Zepbound use and the start of maintenance.
Zepbound 2.5 mg Maintenance Dose: Extreme Fatigue, Feeling Sick Again | Maintenance Diaries Week 2In week 2 of her maintenance diary, Enid Sabel says she is taking her third 2.5 mg Zepbound dose.
How I Prep the Day Before My GLP-1 Shot to Avoid Side Effects (Nausea, Fatigue, GI Issues)In this video, Heather says she is not a doctor and is sharing her own experience.
One year on Zepbound | My Honest Review, Results, & What I've LearnedIn this video, Tasha marks one year on Zepbound and describes how the medication has gone for her.
About Enid Sabel
Patient story, 4.9K subscribers. 8 of their videos are in GLP-1 TV, 155K views between them, mostly on Zepbound.
- 1 Month on Zepbound | Week 4 Results + Starting 5mg (Weight & Inches Lost)
- 3-Month Zepbound Results (Week 12 Update) | GLP-1 Weight Loss Journey, Side Effects & Before + After
- 7 Month Zepbound Update | Week 28, Shot #29, Final Results & Starting Maintenance
Read next
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- GLP-1 constipation, nausea, diarrhoea and fatigue: the label numbers, and what the labels say to do
The four gut effects are the four most common side effects of every GLP-1, and the labels put numbers on them. On Wegovy 2.4 mg: nausea 44%, diarrhoea 30%, constipation 24%, vomiting 24%, fatigue 11%, against 16%, 16%, 11%, 6% and 5% on placebo. On Zepbound at 15 mg: nausea 28%, diarrhoea 23%, constipation 11%, vomiting 13%, fatigue 7%. They cluster around dose increases, they are the reason 6.8% of Wegovy patients and up to 6.7% of Zepbound patients stopped, and both labels prescribe the same fix: climb slower.
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- How long do Ozempic, Wegovy and Zepbound take to work? The label calendar and the trial timepoints
GLP-1s act from the first dose, but the labels start low on purpose and step up every 4 weeks, so most people do not reach a full dose for 3 to 5 months. Each dose reaches steady levels in the blood after about 4 to 5 weeks. In the trials, people averaged 10.6% weight loss after 20 weeks of Wegovy's escalation and 20.9% after 36 weeks of Zepbound, with the full trial results at 68 to 72 weeks. For type 2 diabetes, Ozempic's A1C results were measured at week 30.
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