GLP-1 TV · Patient story · views checked Oct 2026
I tried Zepbound 2.5mg for 2 weeks | Appetite, Weight, & Side Effects
Patient story
Our summary
In this first weigh-in video, Millennial Meg describes the end of her second week on Zepbound 2.5mg. She says she is a 42-year-old mom in perimenopause and a licensed counselor, and she states she is not a doctor or any other medical professional, so everything shared is her own experience. According to the video, she started at 188.4 pounds, lost 2.6 pounds in week one (185.8) and 2.2 more in week two (183.6), for a total of 4.8 pounds. She says she wonders whether she might be a super responder but notes it is early and things may change.
One person's experience, in their words. Not medical advice.
Where Zepbound costs least today
The three cheapest partner programs for Zepbound, all in per month, checked weekly. Brand Zepbound and compounded versions are different products; each row says which it is.
What else the video covers
She also reports tape measurements taken from December 28, 2025. She says her belly at the navel went from 44 to 41 inches, her narrowest waist point from 40 to 36 inches, her hips from 42.5 to 40.5 inches, and her mid thigh dropped one and a half inches. Her arms lost about half an inch and her neck stayed the same. On side effects, she describes feeling very full the morning after each injection, with some nausea, bloating, chills, nasal congestion right after the shot, and heaviness and fatigue within hours. After a larger lunch on the Monday of week two, she says food nearly came back up.
She says appetite suppression is strongest on days one to three of each week, with hunger returning around Wednesday. She says she is on branded Zepbound through the Eli Lilly direct vials program, paid out of pocket, prescribed by her primary care doctor. She hopes to stay on 2.5mg for about eight weeks, plans to update her doctor, and asks viewers how they knew when to move up a dose. She also says she is aware she is very enthusiastic at this stage and that her views may change.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 1:32 She reports going from 188.4 pounds to 183.6 pounds in two weeks, a total loss of 4.8 pounds.
- 3:39 She says her belly measurement fell from 44 to 41 inches and her narrowest waist point from 40 to 36 inches.
- 8:18 She describes post-injection fullness, nausea, chills, nasal congestion, and heaviness with fatigue in the first hours after each shot.
- 14:28 She says appetite suppression is strongest on days one to three of the week and hunger comes back around Wednesday.
- 16:30 She hopes to stay on 2.5mg for about eight weeks and will check in with her doctor about whether to increase the dose.
- 17:30 She says she gets branded Zepbound as vials through the Eli Lilly direct program, paying out of pocket.
Key moments
From the creator's own chapters. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Medication
- Zepbound
- Doses mentioned
- 2.5 mg
- Point in the journey
- Week 2
- Side effects mentioned
- nausea, vomiting, fatigue, bloating and low appetite
- Who is speaking
- Patient
Questions this video answers
How much weight can you lose in the first two weeks on Zepbound 2.5mg?
In this video, Meg says she lost 2.6 pounds in week one and 2.2 pounds in week two, for 4.8 pounds total, going from 188.4 to 183.6 pounds. She says she may be a super responder and expects the pace to slow.
What side effects did she have on Zepbound 2.5mg?
She reports strong fullness the day after each injection, along with some nausea, bloating, chills, brief nasal congestion, and heaviness and fatigue within hours of the shot. She says one oversized lunch nearly made her throw up.
How does appetite change across the week on Zepbound 2.5mg?
She says she felt very full and uninterested in food on the first three days after her shot. Hunger returned around Wednesday and was a little present Thursday, then faded again by Friday.
How did she get Zepbound and what does she pay?
She says she gets branded Zepbound through her primary care doctor using the Eli Lilly direct program, which provides vials paid for out of pocket. She does not state a price in the video.
Videos on the same question
The closest videos in the library by what is said in them, not by title.
1 Month on Zepbound | Week 4 Results + Starting 5mg (Weight & Inches Lost)In this video, a creator who shares lifestyle and faith content covers her fourth week on Zepbound and the start of her second month at 5mg.
One Month Zepbound Journey | Weight Loss Results & Side Effects | 2.5 mgIn this update from the Zepbound and Beyond channel, Anita says she has finished four weeks on Zepbound at 2.5 mg.
5 Months Off Zepbound… Did I Gain It Back? | GLP-1 Update, Food Noise & Real Talk 💭Shemika Seaton says she took Zepbound for about two years, going up to the 15 dose, before stopping cold turkey rather than tapering.
3-Month Zepbound Results (Week 12 Update) | GLP-1 Weight Loss Journey, Side Effects & Before + AfterIn this week 12 update, the creator says she is three months into Zepbound, which she started on July 31st, 2025, and has no regrets.
100lb *ZEPBOUND WEIGHT LOSS* Before and After. Top 10 Strategies for success. No plateausIn this update from the Katie Beats Obesity channel, Katie says she weighed 172.3 lbs that morning, down 2.3 lbs for the week and 100.9 lbs for the year.
7 Month Zepbound Update | Week 28, Shot #29, Final Results & Starting MaintenanceIn this video, Enid Sabel marks the end of the weight loss phase of her Zepbound use and the start of maintenance.
About Millennial Meg’s Health Spot
Patient story, 2.6K subscribers. 10 of their videos are in GLP-1 TV, 96.5K views between them, mostly on Compounded tirzepatide, Zepbound.
- I Moved Up to 5mg Zepbound… a BETTER way
- I Switched to Compounded Tirzepatide
- I tried Zepbound 2.5mg for 3 weeks | SIDE EFFECTS, food, & exercise
Read next
Our guides closest to what this video covers, with prices checked weekly.
- Zepbound dosage chart: every tirzepatide dose, the escalation rule, what each rung lost in the trial, and what it costs
Zepbound has six doses, 2.5 to 15 mg, taken once a week. The label's rule is four weeks at 2.5 mg, then 2.5 mg steps with at least four weeks on each, to a maintenance dose of 5, 10 or 15 mg. In SURMOUNT-1 those three doses lost 15.0, 19.5 and 20.9 percent of body weight over 72 weeks. Direct from Lilly each rung has a price, $299 at 2.5 mg rising to $699 at 10 mg and above, so the chart below carries the dose, the rule, the trial result and the bill in one place, plus the vial and KwikPen concentrations for anyone measuring in units.
- Mounjaro for weight loss, and why Zepbound exists
Mounjaro is tirzepatide approved for type 2 diabetes. Zepbound is the same molecule from the same maker, approved for weight management, and it goes to the same 15 mg. So unlike Ozempic and Wegovy, there is no dose ceiling pushing you from one to the other: the reason people move is coverage and cash price, not strength. Using Mounjaro for weight is off-label and a prescriber's decision. In the one head-to-head trial, tirzepatide beat semaglutide, 20.2% mean body-weight loss at 72 weeks against 13.7%.
- Zepbound side effects: the label's table by dose, who actually quits, and how it compares to semaglutide
Zepbound's label puts a number on every common side effect at each of its three maintenance doses. Nausea runs 25 to 29 percent against 8 on placebo, diarrhoea 19 to 23, vomiting 8 to 13, constipation 11 to 17. Across the two approval trials, 4.8 to 6.7 percent of people stopped the drug because of side effects, against 3.4 percent on placebo, and most of those who quit did so in the first months, from gut effects during dose escalation. Below that table are the rarer things the label warns about, with the trial rates where it gives them, and the honest comparison to Ozempic's table.
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