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GLP-1 TV · Patient story · views checked Oct 2026

My Honest Week 2 Update on Compounded Tirzepatide | What Changed

Patient storyHeather's Health Journey7,858 views6:31Feb 2026

Our summary

In this week two update, Heather describes her experience taking compounded tirzepatide through LLYMD. She says this is her third time on GLP-1 medications in roughly two years, and that she previously used a name-brand drug and semaglutide. She reports low energy all week, no workouts, and an unsettled stomach, which she links possibly to eating more salads than usual and to a Chinese food dinner.

One person's experience, in their words. Not medical advice.

What else the video covers

She says injection night brings back a side effect she remembers from before: very light, restless sleep, which she compares to having caffeine too late. She injects at night because she read online that this avoids daytime nausea, and she asks viewers who inject in the morning to comment on whether it changes things. She also says she has noticed less food noise and is eating less, though she adds that she may just be paying more attention to it.

On weight, she says she started this round at 180.0 pounds, was just under 180 last week, and is now at 178.2 pounds. She attributes the drop to eating less, and possibly water weight or inflammation, and says her clothes do not fit differently yet. She describes herself as a slow loser. Her goal for next week is to track protein and reach 100 g per day, since she wonders whether low intake explains her tiredness. She plans to post twice a week, asks viewers for topic ideas, and notes her husband is a pharmacist while stressing that she is not a doctor and viewers should check with their health care provider.

Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.

Takeaways

The main points, in the order they come up. Tap a time to play from there.

  1. 0:00 Heather says this is her third time on GLP-1s and that she is now on compounded tirzepatide through LLYMD.
  2. 0:31 She reports very low energy, no workouts, and an unsettled stomach during week two.
  3. 1:33 She says injection night, which she does in the evening, brings her worst sleep of the week, a light and restless sleep she also noticed on earlier medications.
  4. 3:36 She reports going from 180.0 pounds at the start to 178.2 pounds this week, about a pound down from last week.
  5. 4:38 She plans to track her protein and aim for 100 g per day next week, wondering if low intake explains her fatigue.
  6. 5:08 She says she wants to post twice a week and reminds viewers to check with their health care provider.

Key moments

From the creator's own chapters. Tap one to play from there.

  1. 0:00 Week 2 update and side effects
  2. 1:06 Injection timing and sleep
  3. 3:16 Weight loss progress
  4. 3:45 Weight update and goals
  5. 5:03 Future content plans

What the video says

As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.

Medication
tirzepatide
Point in the journey
Week 2
Side effects mentioned
nausea and fatigue
Who is speaking
Patient

Questions this video answers

What side effects did she have in week 2 of compounded tirzepatide?

Heather says she had low energy, an unsettled stomach, and poor sleep on injection night. She says she has not worked out all week, and she is unsure whether the stomach issues come from eating more salads or from a Chinese food dinner.

How much weight did she lose after two weeks on compounded tirzepatide?

She says she started at 180.0 pounds and weighed 178.2 pounds at week two, about a pound lower than the previous week. She says she is a slow loser and is comfortable with that pace.

Why does she inject tirzepatide at night?

Heather says she read online, before starting two years ago, that injecting at night helps you skip most nausea. She says it has always been her routine, though she now wonders whether morning injections might help with the poor sleep.

What is her protein goal on tirzepatide?

She says she wants to track her protein next week and reach 100 g every day. She wonders whether not eating enough protein is behind her tiredness and lack of energy to exercise.

Videos on the same question

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About Heather's Health Journey

Patient story, 9.4K subscribers. 8 of their videos are in GLP-1 TV, 290K views between them, mostly on Compounded tirzepatide.

Every Heather's Health Journey video

Read next

Our guides closest to what this video covers, with prices checked weekly.

  • Tirzepatide vs semaglutide: the head-to-head result, and what the better one costs

    They were finally tested against each other. In SURMOUNT-5, 751 adults with obesity took the maximum tolerated dose of one or the other for 72 weeks: tirzepatide lost 20.2% of body weight, semaglutide 13.7%. That gap is real and it is the whole argument for tirzepatide. The other half of the decision is the bill: compounded tirzepatide runs from $85 a month on our board against $69 for semaglutide, and the branded gap is wider still.

  • The best GLP-1 for weight loss, ranked by the evidence and then by the bill

    By weight lost, the order is settled: tirzepatide (Zepbound) first at 20.2% in the only head-to-head, then semaglutide 7.2 mg (Wegovy HD) at 18.7%, then semaglutide 2.4 mg (Wegovy) at 13.7% to 15.6%, then the pills. By what you pay, the order nearly inverts: compounded semaglutide from $69 a month, the Wegovy tablet from $149, Wegovy pen $349, Zepbound $299 to $699 by dose. The best one is where those two lists meet for your budget and your plan.

  • Retatrutide: up to 28.3% weight loss in trials, no FDA approval yet, and no legal way to buy it today

    Retatrutide is Eli Lilly's experimental weekly injection that acts on three hormone receptors (GIP, GLP-1 and glucagon). In the phase 3 TRIUMPH-1 trial, people on the 12 mg dose lost 28.3% of their weight at 80 weeks by Lilly's efficacy measure (25.0% counting everyone randomized). It is not FDA-approved, has no price, and cannot legally be sold. Lilly plans to file with FDA in Q1 2027. Tirzepatide is the closest thing you can buy now, compounded from $85 a month on our board.

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