GLP-1 TV · Patient story · views checked Oct 2026
One year on Zepbound | My Honest Review, Results, & What I've Learned
Our summary
In this video, Tasha marks one year on Zepbound and describes how the medication has gone for her. She says she is 42, a mom of three, and that she feels healthy and can now run. She explains that she went to her doctor on June 20, 2024, because she could not lose weight and has kidney disease and a heart issue. Labs came back showing she was pre-diabetic. She took her first shot on July 1, 2024, and stayed on 2.5 milligrams for about 16 weeks with almost no symptoms apart from one bloating episode.
One person's experience, in their words. Not medical advice.
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What else the video covers
She says she moved up to 5 milligrams after a stall around September or October, then had severe stomach pain in January that sent her to urgent care. Her doctor stopped the medication from January 17 until early March, and she was diagnosed with IBS. She went back on at 2.5 milligrams and says she has had no symptoms since. She reports weighing 176.8 lbs in both January and March, 173 lbs at the time of recording, and a low of 166.6 lbs over the summer, which she puts at almost 35 lbs lost overall. She describes herself as a slow loser and says reduced inflammation, brain fog and food noise mattered more to her than the scale.
She also talks about the emotional side. Because she no longer eats to cope with stress, she says she has to deal with her feelings directly, especially now that she is back in the classroom and doing doctoral work. She is on week eight of Couch to 5K, wants to be 5K ready by next April, and plans to add strength training. She says her doctor does not expect to take her off 2.5 milligrams soon, and she asks viewers to share their own experiences in the comments.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 1:02 Tasha says she saw her doctor on June 20, 2024, found out she was pre-diabetic, and started her shots on July 1, 2024.
- 3:00 She says she spent about 16 weeks on 2.5 milligrams with almost no symptoms, then moved to 5 milligrams after a stall.
- 4:10 She describes severe stomach pain in January, an IBS diagnosis, and a break from Zepbound from January 17 until early March.
- 5:10 Since returning in March at 2.5 milligrams, she says she has had no symptoms and still gets less inflammation, brain fog and food noise.
- 7:12 She reports going from 176.8 lbs in March to 173 lbs, with a low of 166.6 lbs, and says weight loss was secondary for her.
- 10:17 She says she is now running through Couch to 5K, aims to be 5K ready by April, and plans to add strength training.
Key moments
From the creator's own chapters. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Medication
- Zepbound
- Doses mentioned
- 2.5 mg and 5 mg
- Point in the journey
- Year 1
- Side effects mentioned
- fatigue
- Who is speaking
- Patient
Questions this video answers
How much weight did Tasha lose in one year on Zepbound?
She says she has lost almost 35 lbs since starting and weighs 173 lbs at the time of the video. She reports a low of 166.6 lbs over the summer and describes herself as a slow loser.
Can you stay on the 2.5 mg Zepbound dose long term?
Tasha says she has stayed on 2.5 milligrams since returning in March, after trying 5 milligrams for a short time. She says her doctor does not expect to take her off 2.5 milligrams soon as long as she keeps getting benefits and losing.
What side effects did Tasha have on Zepbound?
She says she had almost no symptoms on 2.5 milligrams apart from one bloating episode. She reports severe stomach pain in January after moving to 5 milligrams, which led to an urgent care visit, a pause in treatment and an IBS diagnosis.
What benefits besides weight loss does Tasha describe?
She says she has less inflammation, less brain fog and less food noise, and she links these to her kidney disease. She also says she has more energy and has started running.
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Read next
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- How long do Ozempic, Wegovy and Zepbound take to work? The label calendar and the trial timepoints
GLP-1s act from the first dose, but the labels start low on purpose and step up every 4 weeks, so most people do not reach a full dose for 3 to 5 months. Each dose reaches steady levels in the blood after about 4 to 5 weeks. In the trials, people averaged 10.6% weight loss after 20 weeks of Wegovy's escalation and 20.9% after 36 weeks of Zepbound, with the full trial results at 68 to 72 weeks. For type 2 diabetes, Ozempic's A1C results were measured at week 30.
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Zepbound has six doses, 2.5 to 15 mg, taken once a week. The label's rule is four weeks at 2.5 mg, then 2.5 mg steps with at least four weeks on each, to a maintenance dose of 5, 10 or 15 mg. In SURMOUNT-1 those three doses lost 15.0, 19.5 and 20.9 percent of body weight over 72 weeks. Direct from Lilly each rung has a price, $299 at 2.5 mg rising to $699 at 10 mg and above, so the chart below carries the dose, the rule, the trial result and the bill in one place, plus the vial and KwikPen concentrations for anyone measuring in units.
- Zepbound side effects: the label's table by dose, who actually quits, and how it compares to semaglutide
Zepbound's label puts a number on every common side effect at each of its three maintenance doses. Nausea runs 25 to 29 percent against 8 on placebo, diarrhoea 19 to 23, vomiting 8 to 13, constipation 11 to 17. Across the two approval trials, 4.8 to 6.7 percent of people stopped the drug because of side effects, against 3.4 percent on placebo, and most of those who quit did so in the first months, from gut effects during dose escalation. Below that table are the rarer things the label warns about, with the trial rates where it gives them, and the honest comparison to Ozempic's table.
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