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GLP-1 TV · Patient story · views checked Oct 2026

The Real Cost Of Zepbound - One Month In

Patient storySimply Alexis Hope54,025 views10:37Mar 2025

Our summary

Alexis, who runs the Simply Alexis Hope channel, shares what her first month on Zepbound was like. She says her insurance does not cover weight loss medication, so she gets it directly from Lilly Direct, the manufacturer. Her doctor sent a prescription for 2.5 milligrams, which she describes as the lowest dose. Lilly Direct contacted her by email and text, sent a link to enter her address and payment details, and shipped vials rather than pens. She says syringes cost about $5 extra and arrive in a pack of five, though she only needs four.

One person's experience, in their words. Not medical advice.

What else the video covers

On side effects, she says constipation was the only really bad one she had. She also reports needing a nap after her Saturday injection and says she has not heard others mention this. She describes the medication as quieting "food noise", the constant voice that tells her to eat, which she says is almost gone. She says she now eats to keep her strength and blood sugar steady, can plan meals and stick to them, and finds that eating portions larger than before makes her feel unwell.

She reports going from 209 pounds to 190 pounds in the first month, with about 5 pounds lost in the first week. She says she is also working out and watching what she eats, and that 2.5 milligrams is a starter dose, so smaller early losses are fine. Her tips are to stay hydrated and to avoid alcohol, since she has seen people skip doses to drink. She plans to move to 5 milligrams the next day and asks viewers to comment with their dose and weight loss.

Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.

Takeaways

The main points, in the order they come up. Tap a time to play from there.

  1. 0:30 Alexis says her insurance does not cover weight loss medication, so she orders Zepbound through Lilly Direct with her doctor's prescription.
  2. 2:00 She says Lilly Direct handled shipping by email and text, and she receives vials plus syringes that cost about $5 extra.
  3. 2:31 She reports constipation as her worst side effect, along with drowsiness and a need for a nap after her Saturday injection.
  4. 3:34 She says the medication greatly reduces her "food noise", which helps her plan meals and eat smaller portions.
  5. 6:40 She reports going from 209 pounds to 190 pounds in a month while also exercising and watching her diet.
  6. 7:52 She advises staying hydrated and avoiding alcohol, and says she will move to 5 milligrams the next day.

Key moments

Where the talk turns, found in the captions. Tap one to play from there.

  1. 1:30 Injection technique
  2. 2:49 Side effects
  3. 4:15 Food noise and cravings
  4. 6:37 Weigh-in and results
  5. 8:51 Alcohol

What the video says

As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.

Medication
Zepbound
Doses mentioned
2.5 mg and 10 mg
Point in the journey
Month 1
Side effects mentioned
constipation
Who is speaking
Patient

Questions this video answers

How much weight did she lose on Zepbound in the first month?

Alexis says she went from 209 pounds to 190 pounds in about a month on the 2.5 milligram dose. She says about 5 pounds came off in the first week. She adds that she was also working out and watching what she ate.

What side effects did she have on Zepbound 2.5 mg?

She says constipation was the only really bad side effect. She also reports drowsiness and needing a nap after her Saturday injection, which she says she has not seen others mention.

How does she get Zepbound without insurance coverage?

Alexis says her insurance does not cover weight loss medication, so her doctor sends the prescription to Lilly Direct, the manufacturer. She says they contact her by email and text, she pays through a link, and they ship vials. She says syringes cost about $5 extra.

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Read next

Our guides closest to what this video covers, with prices checked weekly.

  • Zepbound dosage chart: every tirzepatide dose, the escalation rule, what each rung lost in the trial, and what it costs

    Zepbound has six doses, 2.5 to 15 mg, taken once a week. The label's rule is four weeks at 2.5 mg, then 2.5 mg steps with at least four weeks on each, to a maintenance dose of 5, 10 or 15 mg. In SURMOUNT-1 those three doses lost 15.0, 19.5 and 20.9 percent of body weight over 72 weeks. Direct from Lilly each rung has a price, $299 at 2.5 mg rising to $699 at 10 mg and above, so the chart below carries the dose, the rule, the trial result and the bill in one place, plus the vial and KwikPen concentrations for anyone measuring in units.

  • Zepbound without insurance: every dose priced, and what the vial changes

    Without insurance, Zepbound costs $299 a month at the 2.5 mg starting dose and $399 at 5 mg, bought direct from Lilly. From 7.5 mg up the vial and the KwikPen are both $449 a month as long as each refill arrives within 45 days of the last; miss that window and it is $499 at 7.5 mg and $699 from 10 mg. That replaces a list price Lilly itself puts at $499 to $1,086.37 per fill. A year of 13 four-week fills at the trial doses is about $5,800 on refills kept on time and $9,087 at the regular price. Compounded tirzepatide, which is not FDA-approved, starts at $85 a month on our board.

  • How to get Zepbound: who qualifies, who prescribes it, and the four ways to pay

    Zepbound is a prescription drug approved for adults with obesity, or overweight with at least one weight-related condition, which the trials defined as a BMI of 30, or 27 with a comorbidity. Any licensed prescriber can write it, including online. Then it is a payment question with four answers: a commercial plan that covers it brings it to $25 with Lilly's card; Lilly sells it direct for $299 to $699 a month by dose; a plan that refuses can be appealed; and compounded tirzepatide, the same molecule without FDA approval, starts at $85 on our board.

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Side effectsDose changeWeigh-in and resultsFood, protein and eatingFood noise and cravingsInjection techniqueExercise and strengthAlcoholHow it worksConstipation

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