GLP-1 TV · Clinician · views checked Oct 2026
Clinical Trial: Retatrutide Side Effects & Weight Loss Journey
Our summary
A woman enrolled in a retatrutide clinical trial describes her experience in conversation with a host. She says she is in Triumph 3, a trial of obesity and cardiovascular outcomes, and that participants have no control over dosing. After her first four-week box she had lost 6% of her body weight, and the trial then doubled her dose. She says the escalation was very hard, with side effects at the start of each month that eased toward the end, repeated over five boxes. She mentions nausea, vomiting, diarrhea, constipation, skin sensitivity, and a period when she could only take liquids. She says she used Zofran, Imodium and antihistamines, and that once she stopped escalating, the side effects went away.
General education as published by the channel. Not medical advice, and not an endorsement.
Where semaglutide costs least today
The three cheapest partner programs for semaglutide, all in per month, checked weekly. Brand Ozempic and compounded versions are different products; each row says which it is.
What else the video covers
She reports no fatigue on retatrutide, unlike on Saxenda and Ozempic, and says it feels energizing, though she had trouble sleeping the night after injections during escalation. Her resting heart rate is 10 beats per minute higher, which she says she only noticed through blood pressure checks. She explains that the trial is two years long, that Triumph 1 to 4 use a placebo, and that later trials use an older GLP-1 as the comparator. She says protocol deviations, such as dropping a dose, made some people ineligible for extensions, and that diet and exercise guidance is generic, with logging on three days a month.
She says she has 4.5 months left, after which she will be stopped abruptly and barred from other GLP-1 drugs for one month, with blood tests checking drug levels. She plans to discuss a low-dose maintenance drug with her endocrinologist. She says others who stopped regained weight and had inflammation return, and she compares the Australian prices she quotes for Ozempic and Mounjaro with the free drug she receives. The host adds views on food noise and regain.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 0:00 She says she lost 6% of her body weight in the first four weeks, after which the trial doubled her dose.
- 0:31 She describes dose escalation as very hard, repeated five times, with side effects easing once she stopped increasing.
- 2:33 She reports no fatigue on retatrutide, and a resting heart rate about 10 beats per minute higher that she does not feel.
- 3:56 She explains the Triumph trials, noting Triumph 1 to 4 use a placebo and later ones use an older GLP-1.
- 5:37 She says the trial gives only generic diet and exercise advice and requires logging on three days a month.
- 7:37 She says she will be stopped abruptly after 4.5 months and plans to ask about low-dose maintenance.
Key moments
From the creator's own chapters. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Medication
- retatrutide
- Side effects mentioned
- fatigue
- Prices mentioned
- $400 a month and $700 a month
- Who is speaking
- Clinician
Questions this video answers
What side effects did a retatrutide clinical trial participant report?
She says she had nausea, vomiting, diarrhea, constipation and skin sensitivity during dose escalation, and at one point could only take liquids. She reports taking Zofran, Imodium and antihistamines, and says the side effects went away after the fifth box when escalation ended.
How much weight did she lose in the first month of retatrutide?
She says she lost 6% of her body weight in the first four weeks. She adds that the trial then doubled her dose, since participants cannot choose their dosing.
Does retatrutide raise heart rate according to this trial participant?
She says her heart rate is 10 beats per minute higher than before. She reports no shortness of breath, dizziness or palpitations, and says she only noticed it from home blood pressure readings.
What happens at the end of the retatrutide Triumph trial?
She says participants are stopped abruptly with no continued drug, then barred from other GLP-1 medications for one month while blood tests check drug levels. After that, she says she may start another GLP-1 and expects to need a low dose for maintenance.
Videos on the same question
The closest videos in the library by what is said in them, not by title.
Retatrutide, Too Good to Be True? A Dietitian Explains this new GLP-1In this video, Anna Risdorf, a registered dietitian who says she also uses a GLP-1 medication, discusses retatrutide, an experimental drug from Eli Lilly.
Retatrutide Explained: The Triple-Agonist After Ozempic and MounjaroAccording to the video, retatrutide is an investigational once-weekly injection from Lilly, built as a single molecule that activates the GIP, GLP-1 and glucagon receptors.
30% Weight Loss?! Retatrutide CRUSHES ZepboundChristopher Durham of the DOWNSIZED channel reviews the topline results Eli Lilly released for retatrutide in its phase three TRIUMPH-1 trial.
Hit a Weight Loss Plateau on GLP-1s? Doctor Explains Your OptionsIn this video, Dr. Spencer Nadolsky explains how he approaches patients who say they have maxed out their GLP-1 dose and stopped losing weight.
Patients in liver failure after using knock-off weight loss drug | ABC NEWSThis ABC News Australia report follows Megan Hancock, a 32-year-old who became seriously ill after injecting a peptide she bought from a beautician to lose a few kilos.
Read next
Our guides closest to what this video covers, with prices checked weekly.
- Retatrutide: up to 28.3% weight loss in trials, no FDA approval yet, and no legal way to buy it today
Retatrutide is Eli Lilly's experimental weekly injection that acts on three hormone receptors (GIP, GLP-1 and glucagon). In the phase 3 TRIUMPH-1 trial, people on the 12 mg dose lost 28.3% of their weight at 80 weeks by Lilly's efficacy measure (25.0% counting everyone randomized). It is not FDA-approved, has no price, and cannot legally be sold. Lilly plans to file with FDA in Q1 2027. Tirzepatide is the closest thing you can buy now, compounded from $85 a month on our board.
- Stopping a GLP-1: what the withdrawal trials found, and what a maintenance dose actually is
Two trials have measured what happens when you stop. On semaglutide, people who lost 17.3% over 68 weeks regained two-thirds of it in the year after stopping, ending 5.6% below where they started. On tirzepatide, people who lost 20.9% in 36 weeks regained 14% over the next year on placebo while those who continued lost a further 5.5%. Both labels are explicit that these drugs are for maintaining weight reduction long term, which is a different claim from finishing a course. A maintenance dose is simply the dose you stay on; the labels do not define a lower one to step down to at goal.
- Zepbound side effects: the label's table by dose, who actually quits, and how it compares to semaglutide
Zepbound's label puts a number on every common side effect at each of its three maintenance doses. Nausea runs 25 to 29 percent against 8 on placebo, diarrhoea 19 to 23, vomiting 8 to 13, constipation 11 to 17. Across the two approval trials, 4.8 to 6.7 percent of people stopped the drug because of side effects, against 3.4 percent on placebo, and most of those who quit did so in the first months, from gut effects during dose escalation. Below that table are the rarer things the label warns about, with the trial rates where it gives them, and the honest comparison to Ozempic's table.
Find more like it
Side effectsDose changeFood, protein and eatingCost and insuranceExercise and strengthStopping and maintenanceThe trialsFatigue
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