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GLP-1 TV · Patient story · views checked Oct 2026

Wegovy / Semaglutide Compound isn't working | Week 34 Wegovy VLOG

Patient storyMindy Pedersen7,798 views13:42Jul 2022

Our summary

In this week 34 vlog, Mindy Pedersen says her semaglutide compound is not working as well as Wegovy did. She is on the tenth week of a sublingual rapid dissolve tablet, which she says she bought as a 90-day supply without trying it first. She advises others to buy one month before committing. She crushes the tablet, holds it under her tongue for 5 minutes with water, and then swallows it. She says it tastes bad and leaves sores under her tongue.

One person's experience, in their words. Not medical advice.

What else the video covers

She reports that she lost over 10 lbs in her last month on the 2.4 dose of Wegovy, and less than 5 lbs a month since switching to the compound. She says her hunger was not controlled during a California trip and the following weekend. She also mentions the tablet was out of the fridge for about six days and that she had COVID. She asked the pharmacy to switch her back to the subdermal form, which needs her doctor's authorization because the original prescription was for the rapid dissolve. If that does not help, she says she may look for another compounding pharmacy.

The rest of the video covers her mood. She says her birthday plans were canceled because of COVID, her husband was out of town, and she fell into old eating habits without tracking food. By the end of the week she says she was back on her meal plan and feeling better. Her weigh-in went from 293 to 291.5, which she describes as a 1.2 lb gain. She has a follow-up with her doctor next week to discuss the compound.

Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.

Takeaways

The main points, in the order they come up. Tap a time to play from there.

  1. 0:30 She says she has struggled with the sublingual rapid dissolve tablet and bought a 90-day supply without trying it first.
  2. 1:00 She asked the pharmacy to switch her back to the subdermal form, which requires her doctor to authorize a new prescription.
  3. 2:30 She describes crushing the tablet, holding it under her tongue for 5 minutes, and says it tastes awful and leaves sores.
  4. 3:32 She says her loss went from over 10 lbs in her last month on 2.4 Wegovy to under 5 lbs a month on the compound.
  5. 8:48 She says she slipped into old eating habits over her birthday weekend while recovering from COVID and not tracking food.
  6. 11:50 She reports a weigh-in change from 293 to 291.5 and plans to discuss the compound with her doctor at a follow-up next week.

Key moments

From the creator's own chapters. Tap one to play from there.

  1. 0:00 Intro/Semaglutide Compound Dose #10
  2. 5:20 Breakdown Time
  3. 10:16 Lunch w/ Nikki & Results

What the video says

As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.

Medication
Wegovy and semaglutide
Point in the journey
Week 34
Side effects mentioned
fatigue
Who is speaking
Patient

Questions this video answers

Why did she want to stop the sublingual semaglutide compound?

She says the rapid dissolve tablet tasted awful, left sores under her tongue, and seemed to have stopped working. She also reports that her hunger was not controlled and her weight loss slowed.

How much did her weight loss slow after switching from Wegovy to the compound?

She says she lost over 10 lbs in her last month on the 2.4 dose of Wegovy. After switching to the compound she says she lost less than 5 lbs a month.

How does she take the sublingual semaglutide tablet?

She says she crushes the tablet, places it under her tongue with some water, and holds it there for 5 minutes. Then she moves it around and swallows it.

What does she plan to do if the compound still does not work?

She says she will first try the subdermal form for one month. If that fails, she may look for another compounding pharmacy, possibly by asking support groups for people in the Texas area.

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About Mindy Pedersen

Patient story, 17.5K subscribers. 7 of their videos are in GLP-1 TV, 70.3K views between them, mostly on Wegovy, Compounded semaglutide, Mounjaro.

Every Mindy Pedersen video

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    Wegovy HD is semaglutide at 7.2 mg, three times the standard 2.4 mg dose, in its own pen. In the STEP UP trial it took 18.7% off body weight at 72 weeks against 15.6% for 2.4 mg and 3.9% for placebo, in 1,407 adults with obesity. That puts it within 1.5 points of tirzepatide's head-to-head result and makes it the strongest semaglutide there is. Novo sells it direct for $399 a month, $50 above the standard pen, and it sits above the normal ladder rather than replacing it.

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  • Semaglutide side effects, and what compounding does and does not change

    Semaglutide's side effects are gastrointestinal: nausea, vomiting, diarrhoea and constipation, worst early and after each dose increase. Those belong to the molecule, so they are the same whether it came in a Novo Nordisk pen or a compounding pharmacy's vial. What compounding changes is everything around the molecule. A compounded drug is not FDA-approved, so the finished product has not been reviewed for safety, effectiveness or manufacturing quality, and the FDA has said the enforcement discretion that allowed 503A pharmacies to compound semaglutide has ended. It also usually arrives as a vial and a syringe rather than a pre-set pen, which moves dose measurement to you.

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