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GLP-1 TV · Clinician · views checked Oct 2026

Do Ozempic or Mounjaro Cause Depression? (Obesity Doctor Explains)

ClinicianDr. Spencer Nadolsky5,633 views4:39Nov 2025

Our summary

A clinician talks about food noise, cravings and mood on Ozempic, mentioning 10 mg and 15 mg. Also covers mood and mental health, exercise and strength and alcohol.

General education as published by the channel. Not medical advice, and not an endorsement.

Key moments

From the creator's own chapters. Tap one to play from there.

  1. 0:00 Do GLP-1s Cause Depression?
  2. 0:14 Why Early Studies Raised Concerns
  3. 0:46 What FDA and EU Investigations Found
  4. 1:17 How GLP-1s Affect Mood and Reward Pathways
  5. 1:51 The “Zepbound Blahs” and Anhedonia Explained
  6. 2:36 Signs Your Dose Might Be Too High
  7. 3:16 When Lowering the Dose Improves Mood
  8. 3:35 Using Bupropion to Restore Motivation

What the video says

As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.

Medication
Ozempic and Mounjaro
Doses mentioned
10 mg and 15 mg
Who is speaking
Clinician (Dr. Spencer Nadolsky)

Find more like it

Dose changeMood and mental healthExercise and strengthAlcoholStopping and maintenanceHow it worksThe trials

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