GLP-1 TV · Patient story · views checked Oct 2026
First 12 Weeks on Zepbound 2.5mg Side Effects & Weight Loss Progress
Patient story
Our summary
Grace, who runs the channel Losing It Grace, shares an update after her first 12 weeks on Zepbound. She says she is 38 and has tried many approaches to weight loss, including Atkins, South Beach, keto, Mediterranean, calorie counting and heavy exercise. She says she lost weight three times before but regained it within a year each time. Recent blood work showed insulin resistance, pre-diabetes, high blood pressure and high cholesterol, and her doctor asked whether she wanted a tool to help. She took her first 2.5 mg injection on February 25, 2025, after a prior authorization was approved.
One person's experience, in their words. Not medical advice.
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What else the video covers
She reports starting at 265.4 lbs and weighing 252 lbs on May 8, a loss of a little over 13 lbs in 11 weeks. She says she spent the first eight weeks on 2.5 mg, moved to 5 mg, and is in her third week at that dose. Because of her insurance she filled 5 mg as a 3-month supply, so she plans to stay on it at least 12 weeks before considering 7.5 mg. She also gives starting measurements of 50 inches at the stomach, 60 inches at the hips and 47 inches at the chest.
For side effects, she describes a lot of burping and belching, indigestion when she overeats, constipation and occasional diarrhea. After her 10th injection she developed a rash near the injection site, and the same rash appeared in the same spot on the opposite leg. She says she is seeing an allergist to check for a reaction to an inactive ingredient. She also says she thinks about food far less and exercised at the gym on two recent cruises, which she had never done on earlier cruises.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 2:00 Grace says her blood work showed insulin resistance, pre-diabetes, high blood pressure and high cholesterol, which led her doctor to raise a weight loss tool.
- 2:36 She took her first 2.5 mg injection on February 25, 2025, and says constant thoughts about food faded.
- 4:05 She reports going from 265.4 lbs to 252 lbs, a little over 13 lbs in 11 weeks.
- 4:36 She says she spent eight weeks on 2.5 mg, then moved to 5 mg, and plans at least 12 weeks on that dose before considering 7.5 mg.
- 5:38 She lists burping, belching, indigestion from overeating, constipation and occasional diarrhea as her side effects.
- 6:15 After her 10th injection she developed a rash at the injection site that also appeared on the opposite leg, and she is seeing an allergist.
Key moments
From the creator's own chapters. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Medication
- Zepbound
- Doses mentioned
- 2.5 mg and 5 mg
- Point in the journey
- Week 12
- Who is speaking
- Patient
Questions this video answers
How much weight did she lose in 11 weeks on Zepbound?
Grace says she started at 265.4 lbs and weighed 252 lbs on May 8, a little over 13 lbs lost in 11 weeks. She says she was heading into her 12th injection on May 15.
What side effects did she have on Zepbound 2.5 mg and 5 mg?
She reports a lot of burping and belching, indigestion when she overeats, constipation and occasional diarrhea. After her 10th injection she developed a rash near the injection site, which also appeared on the opposite leg.
How long did she stay on the 2.5 mg dose of Zepbound?
Grace says she stayed on 2.5 mg for the first eight weeks, aiming to increase the dose as slowly as possible. She then moved to 5 mg and was in her third week of it.
Does she say you have to increase the Zepbound dose every month?
Grace says that, as she understands it, you do not have to go up every month. She says you can stay on a dose as long as it is working, you feel good and you are losing weight.
Videos on the same question
The closest videos in the library by what is said in them, not by title.
Zepbound Journey Week 1-4: My Experiences and Thoughts #zepbound #glp1In this video, the creator looks back at her first month on Zepbound, a GLP-1 medication she says is used for weight loss.
I tried Zepbound 2.5mg for 2 weeks | Appetite, Weight, & Side EffectsIn this first weigh-in video, Millennial Meg describes the end of her second week on Zepbound 2.5mg.
Lowered My Zepbound Dose and This Happened | A Dietitian's own GLP-1 StoryAnna Reisdorf, a registered dietitian who says she has used GLP-1 medications for 3 years, describes what happened when she lowered her dose after more than a year of weight maintenance.
How I’ve lost Over 30 Pounds | Zepbound Review | Ro Health & 6 Month UpdateIn this video, Dani of the LifeByDani channel gives a review of Zepbound after about 5 to 6 months of use.
About Losing It Grace
Patient story, 23.2K subscribers. 8 of their videos are in GLP-1 TV, 161K views between them, mostly on Zepbound, Wegovy, Compounded tirzepatide.
- Tirzepatide Weight Loss by Dose 💉Which One Worked Best? 75+ LBS Lost
- I Switched to Compounded Tirzepatide After Zepbound
- I Switched to the Zepbound KwikPen: User Guide + 15mg Tirzepatide Titration
Read next
Our guides closest to what this video covers, with prices checked weekly.
- How long do Ozempic, Wegovy and Zepbound take to work? The label calendar and the trial timepoints
GLP-1s act from the first dose, but the labels start low on purpose and step up every 4 weeks, so most people do not reach a full dose for 3 to 5 months. Each dose reaches steady levels in the blood after about 4 to 5 weeks. In the trials, people averaged 10.6% weight loss after 20 weeks of Wegovy's escalation and 20.9% after 36 weeks of Zepbound, with the full trial results at 68 to 72 weeks. For type 2 diabetes, Ozempic's A1C results were measured at week 30.
- Mounjaro for weight loss, and why Zepbound exists
Mounjaro is tirzepatide approved for type 2 diabetes. Zepbound is the same molecule from the same maker, approved for weight management, and it goes to the same 15 mg. So unlike Ozempic and Wegovy, there is no dose ceiling pushing you from one to the other: the reason people move is coverage and cash price, not strength. Using Mounjaro for weight is off-label and a prescriber's decision. In the one head-to-head trial, tirzepatide beat semaglutide, 20.2% mean body-weight loss at 72 weeks against 13.7%.
- Zepbound side effects: the label's table by dose, who actually quits, and how it compares to semaglutide
Zepbound's label puts a number on every common side effect at each of its three maintenance doses. Nausea runs 25 to 29 percent against 8 on placebo, diarrhoea 19 to 23, vomiting 8 to 13, constipation 11 to 17. Across the two approval trials, 4.8 to 6.7 percent of people stopped the drug because of side effects, against 3.4 percent on placebo, and most of those who quit did so in the first months, from gut effects during dose escalation. Below that table are the rarer things the label warns about, with the trial rates where it gives them, and the honest comparison to Ozempic's table.
Find more like it
Side effectsDose changeWeigh-in and resultsFood, protein and eatingFood noise and cravingsInjection techniqueCost and insuranceExercise and strengthStopping and maintenance
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