GLP-1 TV · Patient story · views checked Oct 2026
6 Months on a GLP-1: DEXA Scan & Metabolism Results Revealed
Patient story
Our summary
Lenore, who describes herself as a nutritionist and nutrition coach, reports on six months of using a GLP-1, specifically Zepbound. She says she started at 197.8 lb in August, after a year of no dieting, and was at 173.9 lb by February. By her count the total loss was 33.1 lb, or 16% of her body weight. She walks through the monthly weigh-ins, including a three-week gap in meds from a shipping problem and an 8 lb gain that month, which she attributes mostly to water weight.
One person's experience, in their words. Not medical advice.
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What else the video covers
She then goes through a DEXA scan that cost her $129 (normally $169). She reports body fat at 40.5%, down from 43.6%, and says only 2.7 lb of the 33 lb lost was muscle. She says muscle loss depends on how fast weight comes off, protein intake and strength training, not on the GLP-1 itself. She also reports that her visceral fat rose, and that her bone density of 1.6 was good. She says she eats 100 to 120 g of protein a day and did not lift heavy.
The last part covers a resting metabolic rate (RMR) test. She says hers measured 1312 calories, slow compared with a predicted 1491, which she links to years of low-calorie dieting. She explains how she applies an activity multiplier to get maintenance calories and says this suggests a slow metabolism can make regain faster after stopping. She says she has been off Zepbound 2.5 mg for a few weeks and plans to eat 1310 calories, walk 8000 steps and lift three times a week.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 6:10 She reports losing 33.1 lb (16% of her body weight) over six months, with a three-week medication gap and a temporary 8 lb gain along the way.
- 8:40 She describes the DEXA scan as a full-body scan she paid $129 for, which also measures visceral fat and bone density.
- 11:15 She says only 2.7 lb of her 33 lb loss was muscle, and that muscle loss depends on pace of loss, protein and strength training.
- 17:20 She explains the resting metabolic rate test, which took 10 to 15 minutes with a mask, and reports a slow result of 1312 calories.
- 20:30 She shows how she turns her RMR into maintenance calories and says a slowed metabolism can speed up regain after stopping a GLP-1.
- 28:00 She says she has stopped Zepbound 2.5 mg and lays out a plan of 1310 calories, 8000 steps and three lifting days a week.
Key moments
Where the talk turns, found in the captions. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Doses mentioned
- 2.5 mg
- Point in the journey
- Month 6
- Side effects mentioned
- fatigue and muscle loss
- Who is speaking
- Patient
Questions this video answers
How much muscle did she lose on a GLP-1 in 6 months?
She reports that 2.7 lb of her 33 lb total loss was muscle, based on a DEXA scan. She says she did not lift heavy and ate 100 to 120 g of protein a day.
How much does a DEXA scan cost?
She says her scan at DEXA Fit cost $129 during a special, instead of the usual $169. She says the scan takes about 6 to 8 minutes.
What is a resting metabolic rate (RMR) test and what did hers show?
She describes it as a 10 to 15 minute test where you breathe into a mask while resting, after fasting for at least 6 hours. Her result was 1312 calories, which the report called slow against a predicted 1491 for her age, height and weight.
How much weight did she lose on Zepbound in 6 months?
She says she lost 33.1 lb in total, about 16% of her body weight, going from 207 lb at the start of the year to 173.9 lb. She says 12 lb came off in the first month, much of which she believes was water weight.
Videos on the same question
The closest videos in the library by what is said in them, not by title.
Zepbound Week 61: The Dose Was the ProblemIn this week 61 update, the creator says she gained 13.8 pounds in 11 days after her Zepbound dose was lowered from 5 milligrams to 2.5 milligrams.
I SPENT OVER 2K to LOSE WEIGHT / 6 Months on Zepbound GLP-1 / was it worth it?In this six-month update, a creator who goes by Kristen says she started Zepbound at 205 pounds and is now 161 pounds, a loss of 44 pounds.
GLP-1 / Zepbound / Tirzepatide Journey | 6 Month update, the good and the bad!Luis Zayas, who says he is 32, marks six months on a GLP-1 medication that he started on November 3, 2025.
I Paused Zepbound for 30 days..Here's What HappenedIn this video from December 2025, a nutritionist and health coach who also takes a GLP-1 describes what happened when she stopped Zepbound for about four weeks.
How To Maximize Your GLP-1 Results | Don't Miss This WindowElizabeth, who runs The Betty Method channel, says she lost 99 lb in 13 months using Zepbound.
Stop Losing Muscle on GLP-1s (5 Tricks That Actually Work)In this video, Dr. Dan, who presents himself as an obesity expert, says people taking Ozempic, Wegovy or Zepbound can lose a large share of their weight loss as muscle, up to 40% by his account, if they do not do resistance training.
About Get Fierce with Leo
Patient story, 20.4K subscribers. 5 of their videos are in GLP-1 TV, 448K views between them, mostly on Zepbound.
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- One Month GLP-1 Weight Loss Journey + Side Effects Explained
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Read next
Our guides closest to what this video covers, with prices checked weekly.
- Mounjaro for weight loss, and why Zepbound exists
Mounjaro is tirzepatide approved for type 2 diabetes. Zepbound is the same molecule from the same maker, approved for weight management, and it goes to the same 15 mg. So unlike Ozempic and Wegovy, there is no dose ceiling pushing you from one to the other: the reason people move is coverage and cash price, not strength. Using Mounjaro for weight is off-label and a prescriber's decision. In the one head-to-head trial, tirzepatide beat semaglutide, 20.2% mean body-weight loss at 72 weeks against 13.7%.
- GLP-1 muscle loss: how much of the weight is muscle, and what protects it
On semaglutide or tirzepatide, roughly a quarter to two fifths of the weight you lose is lean mass rather than fat: 25% in tirzepatide's SURMOUNT-1 scan substudy, and 25% to 39% across 20 randomised trials. That share is close to what diet-only weight loss costs. Lean mass is not all muscle, and strength held up in the shorter trials. Resistance training cut the lean share to 17.5% in the pooled trials, and expert groups pair it with enough protein.
- How long do Ozempic, Wegovy and Zepbound take to work? The label calendar and the trial timepoints
GLP-1s act from the first dose, but the labels start low on purpose and step up every 4 weeks, so most people do not reach a full dose for 3 to 5 months. Each dose reaches steady levels in the blood after about 4 to 5 weeks. In the trials, people averaged 10.6% weight loss after 20 weeks of Wegovy's escalation and 20.9% after 36 weeks of Zepbound, with the full trial results at 68 to 72 weeks. For type 2 diabetes, Ozempic's A1C results were measured at week 30.
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