GLP-1 TV · Patient story · views checked Oct 2026
When I Increased My Dose Of Mounjaro/Zepbound | 80lbs Down in 1 Year
Our summary
Jenelle Ketcham walks through the dose-by-dose history of her first year on Mounjaro/Zepbound, which she says ended with 80 pounds lost. She lists the six strengths (2.5, 5, 7.5, 10, 12.5 and 15 mg) and states she is not a doctor and is only sharing her own experience, not medical advice.
One person's experience, in their words. Not medical advice.
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What else the video covers
She says she spent four weeks on 2.5 and lost 15.2 pounds, with fatigue a day or two after each injection and a quick drop in what she calls food noise. She then spent 18 weeks on 5 and lost 44.2 pounds, adding lifting, walking and calorie and protein tracking. She moved her injection day from Sunday to Saturday so side effects would not disrupt her work week. She says her loss slowed around week 16, and she moved up to 7.5 after two more weeks. At that point she was down 59.4 pounds after five and a half months.
On 7.5 she says she spent 10 weeks and lost 8.2 pounds, with no fatigue after the shot. On 10 she reports about 19 weeks with only 5.4 pounds lost, which she links to tracking and working out less. She says she wishes she had rotated injection sites and moved to 12.5 sooner. On 12.5 she lost 7 pounds in about five weeks, skipped one dose because her appetite suppression was so strong, and also cites a shortage. At 56 weeks and 80 pounds down, she plans to go back to 10, which she calls her redemption dose, and to aim for 100 pounds. She notes her dosing may depend on what her pharmacy can supply.
Our summary of what is said, in our words. Doses, results and prices are the speaker’s, not advice.
Takeaways
The main points, in the order they come up. Tap a time to play from there.
- 0:30 She says the six strengths are 2.5, 5, 7.5, 10, 12.5 and 15 mg, and that she started at 2.5.
- 1:02 She reports losing 15.2 pounds in four weeks on 2.5, with mild fatigue and a sharp drop in food noise.
- 3:06 She says she stayed on 5 for 18 weeks, lost 44.2 pounds, and moved her injection day to Saturday to handle fatigue.
- 5:11 She reports losing 8.2 pounds in 10 weeks on 7.5, then only 5.4 pounds on 10 after she tracked and exercised less.
- 6:55 She says she lost 7 pounds in about five weeks on 12.5, and skipped one dose because her appetite suppression was very strong.
- 8:50 At 56 weeks and 80 pounds down, she plans to return to 10 and aim for 100 pounds.
Key moments
From the creator's own chapters. Tap one to play from there.
What the video says
As stated in the video, not checked by us. Doses and results are the speaker’s, not advice.
- Medication
- Zepbound and Mounjaro
- Point in the journey
- Year 1
- Weight loss mentioned
- 80 lb, in the title
- Side effects mentioned
- fatigue, heartburn or reflux and low appetite
- Who is speaking
- Patient
Questions this video answers
How long did she stay on each Mounjaro/Zepbound dose?
She says she spent four weeks on 2.5, 18 weeks on 5, 10 weeks on 7.5, and about 19 weeks on 10. She then reached 12.5 and skipped one dose.
How much weight did she lose on 5 mg of Mounjaro/Zepbound?
She reports losing 44.2 pounds over 18 weeks on 5. She says she also followed a lifting and walking program and tracked her calories and protein.
Why did she say she would change her dosing in hindsight?
She says she probably would have stayed on 2.5 longer, since it already cut food noise and she lost 15.2 pounds. She also says she would have moved to 12.5 sooner and tried other injection sites.
What side effects did she report on Mounjaro/Zepbound?
She reports fatigue a day or two after injections on the lower doses, and mild nausea on 10 for the first time. On 12.5 she says appetite suppression was so strong she had to remind herself to eat.
Videos on the same question
The closest videos in the library by what is said in them, not by title.
MOUNJARO UK: A LOOK BACK AT MY GLP-1 MASSIVE WEIGHT LOSS JOURNEY | -80lbs ✨🎀Aimee May, a UK creator who says she is 4 ft 11, looks back on her time on Mounjaro.
Mounjaro Weight Loss Timeline: 1 Month vs 3 vs 6 vs 12… What REALLY HappensJenelle Ketcham, who goes by Jen, says she has been on a GLP-1 medication for 2.5 years and has lost 90 lb.
92lbs Lost in 7 Months: Which Is The Best Dose Of Mounjaro?K Eddie says they lost 92 pounds in 7 months on Mounjaro, from 1 May 2025 to 7 November 2025, starting at nearly 300 lb after 25 years of failed diets.
MOUNJARO/ZEPBOUND | When should you increase your dose?!In this video, Brittany, who says she has lost 83 lbs on Mounjaro, shares her approach to deciding when to increase or decrease a Mounjaro or Zepbound dose.
MOUNJARO FOR WEIGHT LOSS | Week 5, 1st dose of 5 MG | New Symptoms?!Brittany Rose, who posts as Brittany Rose GLP1, covers her first week on the 5 MG dose of Mounjaro, which is week 5 of her treatment.
Down 21lbs in my first 2 months on Mounjaro! GLP-1 Journey, Weight-loss, Tirzepatide; Kiala GreensIn this two-month update, Keisha says she started her injections on April 25th and has been on the lowest dose, 2.5 milligrams of tirzepatide, the active ingredient she names as being in Mounjaro.
Read next
Our guides closest to what this video covers, with prices checked weekly.
- Mounjaro for weight loss, and why Zepbound exists
Mounjaro is tirzepatide approved for type 2 diabetes. Zepbound is the same molecule from the same maker, approved for weight management, and it goes to the same 15 mg. So unlike Ozempic and Wegovy, there is no dose ceiling pushing you from one to the other: the reason people move is coverage and cash price, not strength. Using Mounjaro for weight is off-label and a prescriber's decision. In the one head-to-head trial, tirzepatide beat semaglutide, 20.2% mean body-weight loss at 72 weeks against 13.7%.
- Mounjaro side effects: the label's numbers by dose, the low blood sugar risk, and how tirzepatide compares at weight-loss doses
On Mounjaro's own label, the common side effects are stomach ones and they rise with the dose: nausea in 12, 15 and 18 percent of people at 5, 10 and 15 mg against 4 percent on placebo, diarrhea 12 to 17 against 9, and any gastrointestinal reaction in 37 to 44 percent against 20. Most of it happens while the dose is being raised and fades. Low blood sugar is rare on Mounjaro alone and is mainly a risk when it is added to insulin or a sulfonylurea. Below: the full table, the rare warnings, and why Zepbound's numbers for the same molecule look higher.
- Zepbound vs Mounjaro: one molecule, two labels, and why the label sets your price
Zepbound and Mounjaro are both tirzepatide, made by Lilly, injected weekly at the same six doses from 2.5 to 15 mg. Mounjaro is approved for type 2 diabetes and Lilly's own site says it is not a weight-loss drug; Zepbound is the same molecule approved for obesity and sleep apnoea. That label decides everything downstream: insurers cover Mounjaro for diabetes and refuse it for weight, Zepbound is the box a plan can cover for weight, and Zepbound's cash price runs $299 to $699 by dose, while LillyDirect sells Mounjaro from $499 a month at every strength, against a list price of $1,112.16 per fill.
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Side effectsDose changeWeigh-in and resultsFood, protein and eatingFood noise and cravingsInjection techniqueExercise and strengthFatigueHeartburn or refluxLow appetite
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