DOWNSIZED

In this beginner guide from the DOWNSIZED channel, Christopher Durham walks through unboxing and using his first Zepbound QuickPen.

1. 0:00 Welcome to KwikPen
2. 0:58 Ordering and Unboxing
3. 1:16 Guides Storage and Dosing
4. 3:22 What Comes in the Pouch
5. 4:21 Meet the Zepbound 15mg Pen
6. 6:24 Safety Checks and Prep
7. 7:21 Attach Needle and Prime
8. 10:55 Pick Site and Dial Dose

• Doses mentioned: 5 mg, 10 mg and 15 mg
• Prices mentioned: $600 a year
• Who is speaking: Patient

A patient shares their experience with a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

Christopher Durham, who runs the DOWNSIZED channel with his wife Loren, shares ten tips aimed at men using GLP-1 medications for obesity. He says he has used Zepbound, Mounjaro and compounded semaglutide, and that all three worked the same for him.

1. 0:00 Introduction and Personal Journey
2. 0:27 Understanding GLP-1 Medications
3. 2:53 Effective Use of GLP-1 Medications
4. 4:59 Managing Fatigue and Prioritizing Rest
5. 6:23 Adapting to Appetite Changes
6. 10:27 Mental Health and Emotional Wellbeing
7. 11:49 Importance of Hydration
8. 12:56 Setting Boundaries for Success

• Weight loss mentioned: 30 lb
• Side effects mentioned: constipation, diarrhea and fatigue
• Who is speaking: Patient

A patient shares a Year 2 update on a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Point in the journey: Year 2
• Who is speaking: Patient

A patient shares a Month 1 update on a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Point in the journey: Month 1
• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel reviews two Eli Lilly maintenance studies presented at the European Conference on Obesity in Istanbul. He says SURMOUNT MAINTAIN (The Lancet) and ATTAIN MAINTAIN (Nature Medicine) are randomized, placebo-controlled phase 3b trials.

1. 0:00 Life After Weight Loss
2. 1:21 Meet The Downsized
3. 2:35 New Maintenance Studies
4. 4:25 How SURMOUNT Works
5. 5:47 Full Dose Holds Line
6. 7:14 Lower Dose vs Placebo
7. 9:43 Why Regain Happens
8. 12:50 Health Markers Matter

• Who is speaking: Patient

Lorraine Durham, who hosts the DOWNSIZED channel, says she has lost 50 lbs on compounded tirzepatide and describes the breakfasts and lunches she relies on.

1. 0:00 Introduction to GLP-1 Medications and Weight Loss
2. 0:13 High Protein Diet for Weight Loss
3. 0:32 About the Channel and Disclaimer
4. 0:56 Daily Protein Goals and Tracking
5. 3:06 Breakfast: High Protein Options
6. 5:42 Lunch: Easy and Protein-Packed Meals
7. 8:13 Fast Food and Eating Out Tips
8. 9:14 Conclusion and Additional Tips

• Weight loss mentioned: 50 lb, in the title
• Who is speaking: Patient

In this video from the DOWNSIZED channel, Lorraine Durham says she lost 50 pounds on compounded tirzepatide, which she obtained through Mochi Health Online because her insurance does not cover weight loss medications.

1. 0:00 Introduction
2. 0:50 Securing Your Medication
3. 1:42 Tracking Your Progress
4. 2:54 High Protein Diet Tips
5. 5:45 Importance of Hydration
6. 6:38 Exercise Recommendations
7. 7:29 Avoiding Alcohol
8. 8:24 Bonus Tip: Managing Your Dose

• Doses mentioned: 10 mg
• Weight loss mentioned: 50 lb, in the title
• Side effects mentioned: nausea and constipation
• Who is speaking: Patient

A patient talks through a GLP-1 side effects. Side effects mentioned: fatigue.

• Side effects mentioned: fatigue
• Who is speaking: Patient

In this short video, a woman who gives her name as Lurine Duram shows how she gives herself her weekly injection of compounded tirzepatide.

1. 0:00 Introduction to Tirzepatide Injection
2. 0:25 Preparing for the Injection
3. 1:13 Executing the Injection
4. 2:13 Post-Injection Care and Storage

• Who is speaking: Patient

Lorraine Durham, who runs the DOWNSIZED channel, describes losing 50 pounds in 39 weeks on combination tirzepatide from a compounding pharmacy, which she gets through the telemedicine service Mochi Health. She says she is not a doctor and that this is her personal experience.

1. 0:00 Introduction and Welcome
2. 0:32 Struggles with Weight Loss
3. 2:04 Discovering Mounjaro
4. 3:05 Starting the Medication
5. 4:48 Tracking Progress and Adjusting Doses
6. 5:52 Dealing with Side Effects
7. 7:51 Hitting Milestones and Challenges
8. 10:01 Maintaining Weight Loss

• Doses mentioned: 5 mg, 7.5 mg, 10 mg and 12.5 mg
• Weight loss mentioned: 50 lb, in the title
• Side effects mentioned: constipation and fatigue
• Who is speaking: Patient

In this 7:33 video from the DOWNSIZED channel, Lorraine Durham explains how she decides when to move up a dose of compounded tirzepatide, the generic name for Mounjaro and Zepbound. She says she has lost over 45 pounds on it.

1. 0:00 Introduction to Weight Loss with GLP-1 Medications
2. 0:27 Understanding Dosages and Starting Your Journey
3. 1:16 Navigating Side Effects and Dosage Adjustments
4. 1:39 Maximizing Weight Loss: Dosage Strategy and Personal Observa
5. 3:41 Lifestyle Considerations and Managing Expectations
6. 5:27 Consistency Over Speed: The Long-Term Weight Loss Strategy
7. 6:05 Fine-Tuning Dosage Towards Goal Weight and Maintenance
8. 7:05 Conclusion and Final Thoughts

• Doses mentioned: 2.5 mg, 5 mg, 12.5 mg and 15 mg
• Side effects mentioned: nausea and constipation
• Who is speaking: Patient

In this weekly weigh-in from the DOWNSIZED channel, married hosts Lorraine and Christopher Durham record from a park on July 13, 2025. They say they are not doctors and tell viewers to take medical questions to their own doctor.

1. 0:00 Introduction and Welcome
2. 0:11 Our Weight Loss Journey
3. 1:58 Current Weigh-In and Progress
4. 6:14 Understanding GLP-1 Medications
5. 14:16 Q&A Session
6. 18:27 Exercise and Fitness Tips
7. 22:31 Upcoming Events and Meetups
8. 24:36 Conclusion and Farewell

• Doses mentioned: 2.5 mg, 5 mg, 7.5 mg and 15 mg
• Weight loss mentioned: 50 lb
• Side effects mentioned: loose skin or face changes
• Who is speaking: Patient

A patient explains how tirzepatide works and what the evidence says. They report losing 60 lb, as the title says.

• Weight loss mentioned: 60 lb, in the title
• Who is speaking: Patient

In this interview on the DOWNSIZED channel, host Lorraine Durham, who says she has lost 53 pounds with GLP-1 medications, talks with Dr. Spencer Nadolsky.

1. 0:00 Introduction and Guest Introduction
2. 1:56 Understanding GLP-1 Medications
3. 7:33 Side Effects and Weight Loss Management
4. 21:15 Protein Shakes and Red Meat: Benefits and Risks
5. 24:34 Debunking Diet Myths and Misinformation
6. 32:07 Future of GLP-1 Medications and Obesity Treatment
7. 40:38 Battling Insurance Companies for Weight Loss Medications
8. 41:53 The Future of GLP-1 Medications

• Doses mentioned: 2.4 mg, 3 mg, 12.5 mg and 15 mg
• Side effects mentioned: nausea, constipation, diarrhea, hair loss, heartburn or reflux, gallbladder and pancreatitis
• Prices mentioned: $50 a month
• Who is speaking: Patient

A patient talks about a GLP-1 doses and moving up. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient looks at what a GLP-1 costs and how coverage works. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient shares their experience with a GLP-1. They report losing 150 lb, as the title says.

• Weight loss mentioned: 150 lb, in the title
• Who is speaking: Patient

A patient looks at what Zepbound costs and how coverage works. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel reports on the new Zepbound QuickPen from Eli Lilly, which he says is now available in the United States through Lilly Direct for cash-pay patients.

1. 0:00 Breaking: Could Zepbound Start $200/Month Cheaper?
2. 0:48 What’s New: Zepbound Kwikpen Arrives in the U.S.
3. 0:57 Kwikpen Basics: Multi‑Dose Pen + Available Strengths
4. 1:20 How It Differs From the Single‑Use Autoinjector
5. 1:38 The 3 Ways to Get Zepbound: Overview
6. 1:53 Path #1: Insurance Coverage (Nothing Changes)
7. 2:16 Path #2: Insured but Not Covered, $499 Savings Card Explaine
8. 2:58 Path #3: Cash Pay via Lilly Direct, Vials or Kwikpen

• Doses mentioned: 2.5 mg, 7.5 mg, 10 mg and 12.5 mg
• Prices mentioned: $200 a month, $25 a month and $499 a month
• Who is speaking: Patient

Christopher Durham of the channel DOWNSIZED walks through the Medicare GLP-1 Bridge, a temporary federal demonstration program that he says runs from July 1st, 2026 through December 31st, 2027.

1. 0:00 July 1 Launch Alert
2. 0:33 Why This Matters
3. 3:57 WHAT IS THE MEDICARE GLP-1 BRIDGE?
4. 5:25 What Happens After 2027
5. 6:51 Weight Loss Only Rules
6. 8:39 WHICH MEDICATIONS ARE COVERED?
7. 9:27 WHO IS NOT ELIGIBLE
8. 11:16 WHO DOES QUALIFY?

• Prices mentioned: $50 a month and $650 a month
• Who is speaking: Patient

A patient talks about a GLP-1 doses and moving up. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient explains how Wegovy works and what the evidence says. Also covers stopping and maintenance.

• Who is speaking: Patient

This is the first episode of Ask Downsized, a Sunday question-and-answer show from hosts Christopher and Lorraine Durham.

1. 0:00 Food Noise Is Back on My GLP-1! Should I Increase My Dose? A
2. 2:54 Gained 6 Pounds on Vacation, Now What?
3. 15:45 Could Shaq Appear on The Downsized?
4. 16:31 Do Tirzepatide Results Apply to Wegovy?
5. 17:22 Why Does My Skin Hurt on GLP-1s?
6. 18:35 Compounded Tirzepatide Expiration Dates
7. 20:35 Medicare Bridge and Zepbound Click Pens
8. 20:50 Changing Zepbound Doses on Medicare Bridge

• Doses mentioned: 2.5 mg and 5 mg
• Weight loss mentioned: 55 lb
• Prices mentioned: $199 a month, $79 a month and $450 a month
• Who is speaking: Patient

A patient looks at what a GLP-1 costs and how coverage works. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel gives a plain-language overview of the Medicare GLP-1 Bridge Short-Term Demonstration. He says it starts July 1 and is scheduled to end at the end of 2027.

1. 0:00 50 GLP-1s? Here’s How the Medicare Bridge Works
2. 3:02 THE BRIDGE PROGRAM
3. 5:34 DO YOU QUALIFY
4. 8:40 THE ONE THING PEOPLE GET WRONG
5. 10:35 HOW TO MAKE IT HAPPEN
6. 13:01 THE MONEY, AND THE CATCHES
7. 15:03 WHAT TO UNDERSTAND BEFORE YOU START
8. 17:05 QUICK ANSWERS

• Prices mentioned: $50 a month and $245 a month
• Who is speaking: Patient

In this video, Christopher and Lorraine Durham of the DOWNSIZED channel look back on two years of GLP-1 treatment. They say they started on the same day, September 29, 2023, after the medication sat in their refrigerator for about a month.

1. 0:00 Introduction to journey
2. 1:02 Starting the medication
3. 6:17 First weeks and effects
4. 10:48 Overcoming food noise
5. 14:35 Rapid weight loss phase
6. 17:10 Starting the YouTube channel
7. 21:06 Non-scale victories
8. 25:27 Mindset shift on obesity

• Doses mentioned: 10 mg, 12.5 mg and 15 mg
• Point in the journey: Year 2
• Weight loss mentioned: 150 lb, in the title
• Side effects mentioned: constipation and fatigue

Hosts Christopher and Lorraine Durham interview Dr. G, a Hollywood, Florida doctor who runs a hybrid practice, half direct primary care and half insurance-based, and who makes GLP-1 education videos.

1. 0:00 Introduction and backgrounds
2. 2:35 Meet Dr. G and his practice
3. 4:20 Direct primary care model
4. 5:39 Educating on obesity
5. 8:07 Approaching weight with patients
6. 10:28 Entertaining medical education
7. 12:54 Ways to work with Dr. G
8. 14:16 Choosing the right GLP-1

• Doses mentioned: 2.5 mg, 7.5 mg and 15 mg
• Side effects mentioned: nausea, vomiting, constipation, fatigue and muscle loss
• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel reviews the 2026 Zepbound Savings Card terms, which he says Eli Lilly updated on its website on December 22, 2025 without a press release.

1. 0:00 2026 Zepbound updates
2. 1:28 Savings card changes
3. 3:37 Cash pay vs insurance
4. 5:58 Future strategy and pressure
5. 7:44 Direct sales impact
6. 9:19 Conclusion and call to action

• Doses mentioned: 2.5 mg, 5 mg, 10 mg and 15 mg
• Prices mentioned: $25 a month, $499 a month and $299 a month
• Who is speaking: Patient

A patient shares a Week 72 update on a GLP-1. Also covers stopping and maintenance.

• Point in the journey: Week 72
• Who is speaking: Patient

A patient demonstrates the Zepbound injection, step by step. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient looks at what a GLP-1 costs and how coverage works. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

In this DOWNSIZED video, Laraine Durham, a 55-year-old woman who says she started at 193 lbs, reports her month-by-month results over six months on tirzepatide, which she says is also sold as Mounjaro and Zepbound.

1. 0:00 How Long does it take - L
2. 0:08 Setting Expectations: How Long Will Weight Loss Take?
3. 0:45 The Journey Begins: Tracking Progress and Overcoming Holiday
4. 1:56 Personal Milestones: Celebrating Weight Loss Successes
5. 2:36 Adjusting Dosages and Navigating Challenges
6. 8:26 Learning from the Journey: What Made This Time Different
7. 10:45 Conclusion: Your Personal Journey and Next Steps

• Doses mentioned: 5 mg, 7.5 mg and 10 mg
• Who is speaking: Patient

A patient looks at what a GLP-1 costs and how coverage works. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient looks at what a GLP-1 costs and how coverage works. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

Lynn, a 56-year-old stay-at-home mom from the Chicago area, talks with host Lorraine Durham on The Downsized Dish about her weight loss on Zepbound.

1. 0:00 Welcome to The Downsized
2. 0:59 Meet Lyn in Chicago
3. 2:13 Weight Struggles Begin
4. 3:56 Vacation Turning Point
5. 6:07 Paying for Zepbound
6. 6:58 Staying on 2.5mg
7. 7:28 Progress Stats and Photos
8. 8:28 Goal Weight Plans

• Doses mentioned: 2.5 mg
• Weight loss mentioned: 72 lb, in the title
• Side effects mentioned: nausea, constipation, loose skin or face changes and low appetite
• Who is speaking: Patient

A patient talks through Ozempic side effects. Side effects mentioned: loose skin or face changes.

• Side effects mentioned: loose skin or face changes
• Who is speaking: Patient

A patient shares a Month 2 update on a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Point in the journey: Month 2
• Who is speaking: Patient

In this weekly Q&A episode, the hosts Lorraine and Christopher Durham answer viewer questions about tirzepatide and other GLP-1 medications.

1. 0:00 How Much Weight Can You Really Lose on Zepbound? Ask the DOW
2. 2:08 Questions
3. 2:41 Where Are the KwikPen Needles?
4. 4:46 Can You Stop Taking GLP-1s?
5. 7:00 Do You Prime the KwikPen Every Time?
6. 7:58 Does the Full Feeling Go Away?
7. 9:48 Are there Any GLP-1 Drugs That Won't Make you Sick?
8. 13:26 Which Telehealth Company Should You Choose?

• Doses mentioned: 7.5 mg, 10 mg, 12.5 mg and 15 mg
• Weight loss mentioned: 50 lb
• Side effects mentioned: nausea, constipation, diarrhea, headache, hair loss, dizziness, loose skin or face changes and dehydration
• Prices mentioned: $50 a month and $449 a month

Christopher Durham of the channel DOWNSIZED, who says he and his wife Lorraine have lost more than 150 lb using GLP-1s, walks through two CMS programs for Medicare GLP-1 coverage. He says he is not a doctor and this is not medical advice.

1. 0:00 50 GLP-1s? Medicare Update: Everything You Need to Know
2. 2:12 Why This Matters
3. 4:42 Current Medicare Reality
4. 5:55 Two Program Rollout
5. 7:06 Bridge Program Basics
6. 9:29 How To Apply
7. 11:23 Eligibility Tiers
8. 13:23 BMI Rules Clarified

• Prices mentioned: $245 a month and $50 a month
• Who is speaking: Patient

A patient talks about stopping a GLP-1 and what came after. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

In this weekly question-and-answer episode, Lorraine and Christopher Durham answer viewer comments about tirzepatide. They say they are patients, not doctors, and that their answers come from personal experience, conversations with doctors and other patients, and research.

1. 0:00 GLP-1 Plateaus, Hair Loss, Nausea & Maintenance: What You Ne
2. 2:57 Obesity is a Disease
3. 3:55 Ask the Downsized
4. 3:59 GLP-1 Weight Loss Plateau: What Should You Do?
5. 10:29 GLP-1 Not Feeling Different: Is It Still Working?
6. 14:28 GLP-1 Pills vs. Injections?
7. 15:27 What Is the Hume Body Pod?
8. 18:22 Can Wegovy or GLP-1s Cause Hair Loss?

• Doses mentioned: 5 mg, 7.5 mg, 10 mg and 12.5 mg
• Weight loss mentioned: 22 kg
• Side effects mentioned: nausea, vomiting, hair loss and muscle loss
• Who is speaking: Patient

A patient explains how Foundayo works and what the evidence says. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

In this interview, Giorgia Rutigliani, a PhD candidate in nutrition science at Purdue University, describes a study on why people eat less on GLP-1 medications.

1. 0:00 Welcome to The Downsized
2. 1:02 Meet Giorgia and Her Research
3. 4:35 Why Study GLP-1 Effects
4. 7:07 From Anecdotes to Study Design
5. 9:41 Chemosensory Testing Methods
6. 13:46 Sample Makeup and Med Types
7. 16:03 Results Taste and Smell
8. 19:32 Big Finding Food Noise Drops

• Who is speaking: Patient

Christopher Durham of The Downsized says Eli Lilly made two linked announcements about orforglipron, its once daily oral GLP-1 drug.

1. 0:00 Breaking News: A New Obesity Medication
2. 2:19 Eli Lilly's Major Announcement
3. 4:28 Clinical Trial Insights: Attain Maintain
4. 11:21 The Importance of Accessibility and Affordability
5. 14:13 Engaging the Community: Your Thoughts
6. 15:07 Conclusion: The Future of Obesity Treatment

• Prices mentioned: $149 a month, $399 a month and $99 a month
• Who is speaking: Patient

Christopher Durham, who runs the DOWNSIZED channel with his wife Lorraine, explains what he calls food noise: constant mental chatter about what to eat that does not depend on being hungry or full.

1. 0:00 Introduction: The Unending Voice of Hunger
2. 0:11 Breakthrough Research on Food Noise
3. 1:18 Personal Journey: Overcoming Food Noise
4. 1:53 Understanding Food Noise
5. 3:21 The Impact of Tirzepatide
6. 5:48 Scientific Study on Tirzepatide
7. 11:55 Neurological Changes Observed
8. 17:05 Limitations and Future Questions

• Doses mentioned: 2.5 mg
• Side effects mentioned: fatigue
• Who is speaking: Patient

This is a weekly Q&A episode from the DOWNSIZED channel, hosted by married couple Lorraine and Christopher Durham. Lorraine says she weighs 147.6 pounds, up from her usual 145, and explains that her smart scale shows lean mass up about 3 to 4 pounds since October.

1. 0:00 Welcome
2. 2:24 Weekly Weigh In Begins
3. 2:37 Laraine's Weekly Weigh-In
4. 3:38 Muscle Gain and Maintenance
5. 7:55 Europe Trip Recap
6. 9:10 Chirstopher's Weekly Weigh-in
7. 12:24 Downsized at Sea Cruise
8. 13:07 Post Travel Reset Tips

• Doses mentioned: 7.5 mg, 10 mg and 15 mg
• Side effects mentioned: muscle loss
• Prices mentioned: $79 a month and $199 a month
• Who is speaking: Patient

A patient explains how Zepbound works and what the evidence says. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

This is the weekly Downsized News roundup from March 2, 2026, hosted by Christopher and Lorraine Durham, a couple who say they began using GLP-1s in September 2023. They cover eleven stories, and say they are not doctors and that the commentary reflects their own experience.

1. 0:00 Novo Slashes GLP-1 List Prices! Downsized News
2. 2:01 Orforglipron Beats Oral Semaglutide in Phase 3 Trial
3. 6:13 Congress Advances PBM Reform
4. 10:26 Planet Fitness Sees GLP-1 Membership Surge
5. 16:14 Genetics May Predict GLP-1 Response
6. 21:02 Novo to Cut List Prices by 2027
7. 25:15 UK Ties Physician Bonuses to GLP-1s
8. 27:42 AI-Built Oral GLP-1 Enters Phase 3

• Doses mentioned: 9 mg
• Prices mentioned: $25 a month, $675 a month and $245 a month
• Who is speaking: Patient

This weekly news episode from the hosts of DOWNSIZED covers eight GLP-1 stories. The hosts say they have taken tirzepatide since September 2023, have lost more than 150 lb between them, and have never had a dose covered by insurance.

1. 0:00 Shaquielle O'Neal Just Confirmed He's on Zepbound!
2. 2:06 Shaq on Zepbound
3. 5:26 GLP-1s Cut Mortality 44% in Autoimmune Patients
4. 9:25 GLP-1s Could Save $193,000 Per Patient
5. 13:43 Wegovy Pill Hits the UK
6. 16:37 Foundayo Beats Oral Semaglutide Head-to-Head
7. 20:38 GLP-1 Coverage: What Payers and Employers Are Actually Doing
8. 25:13 Lilly's $200M Rebate Fraud Case

• Who is speaking: Patient

This is a weekly live Q&A from the DOWNSIZED channel, hosted by married couple Lorraine and Christopher Durham. They say they are patients, not doctors.

1. 2:39 Cost and insurance
2. 27:01 Dose change
3. 32:06 Injection technique
4. 50:26 Exercise and strength
5. 1:08:16 Food, protein and eating
6. 1:20:34 Dose change
7. 1:36:11 Cost and insurance
8. 1:52:40 Weigh-in and results

• Doses mentioned: 5 mg, 10 mg, 12.5 mg and 15 mg
• Weight loss mentioned: 50 lb
• Side effects mentioned: nausea, constipation, fatigue, hair loss, heartburn or reflux, loose skin or face changes and muscle loss
• Prices mentioned: $90 a month, $60 a month and $199 a month

A patient talks about Zepbound doses and moving up. They report losing 92 lb, as the title says.

• Weight loss mentioned: 92 lb, in the title
• Who is speaking: Patient

A patient shares their experience with Wegovy. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient talks about tirzepatide doses and moving up. Prices mentioned: $99 a month and $199 a month.

• Prices mentioned: $99 a month and $199 a month
• Who is speaking: Patient

According to the video, Christopher Durham of the DOWNSIZED channel walks through 10 points from Eli Lilly's Q1 2026 earnings call, held April 30, 2026, and translates them for patients.

1. 0:00 Eli Lilly Just Proved GLP-1 Prices Could Be Lower… Here’s th
2. 1:54 Eli Lilly's Q1 2026 Earnings Call
3. 2:28 10 Things That Mattered
4. 2:34 1. The Pill is Real.
5. 4:24 2. If you are on Medicare, July 1st is your date
6. 6:40 3. The chart that proves everything we have been saying abou
7. 9:30 4. If you self-pay for Zepbound, you are now part of the maj
8. 10:30 5. Ask your employer about Lilly Employer Connect

• Prices mentioned: $50 a month
• Who is speaking: Patient

In this weekly live Q&A, the hosts of DOWNSIZED say they are not doctors. Christopher says he went from 286.4 pounds to about 185 pounds, taking Zepbound, Mounjaro and compounded tirzepatide, with about a year at a 15 or 16 milligram dose.

1. 2:19 Dose change
2. 23:35 Food, protein and eating
3. 32:58 Exercise and strength
4. 58:24 Food, protein and eating
5. 1:12:21 Dose change
6. 1:36:14 Cost and insurance
7. 1:45:15 Dose change
8. 1:55:19 Weigh-in and results

• Doses mentioned: 2.5 mg, 5 mg, 7.5 mg and 15 mg
• Weight loss mentioned: 100 lb
• Side effects mentioned: nausea, constipation, diarrhea and loose skin or face changes
• Prices mentioned: $400 a month and $280 a month

Christopher Durham, host of the DOWNSIZED channel, compares his experience with branded tirzepatide (Mounjaro and Zepbound) and compounded tirzepatide from telehealth providers.

1. 0:00 Who Wins? Zepbound & Mounjaro vs. Compounded
2. 0:26 The Downsized
3. 0:48 My Weight Loss Journey: A Personal Story
4. 1:07 Comparing Branded and Compounded GLP-1 Medications
5. 1:51 The Journey with Mounjaro and Zepbound
6. 3:17 Pros and Cons of Branded Medications
7. 6:04 Exploring Compounded Medication Options
8. 9:18 Final Thoughts and Recommendations

• Doses mentioned: 2.5 mg and 10 mg
• Prices mentioned: $100 a month
• Who is speaking: Patient

A patient walks through their time on a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

Christopher Durham of the channel DOWNSIZED says that, as of March 8, 2026, there are no $50 per month Zepbound or Wegovy prescriptions available through Medicare for obesity.

1. 0:00 Medicare $50 Confusion
2. 1:08 Channel Intro and Disclaimer
3. 2:08 Reality at the Pharmacy Today
4. 4:34 Where $50 Came From
5. 6:25 Balance Model Explained
6. 8:45 Timeline and Eligibility Unknowns
7. 10:23 Voluntary Participation Limits
8. 11:35 Laws Blocking Coverage and Coupons

• Prices mentioned: $50 a month
• Who is speaking: Patient

A patient shares their experience with Wegovy. Also covers injection technique.

• Who is speaking: Patient

Christopher Durham of the channel DOWNSIZED reacts to the FDA approval of orforglipron, which Eli Lilly is calling FOUNDAYO. He says he is not a doctor and that the video is not medical advice.

1. 0:00 Introduction to the channel
2. 1:08 FDA approval of Foundayo
3. 1:58 Clinical results and ease
4. 2:53 Market strategy and pricing
5. 3:49 Value proposition analysis
6. 5:29 Industry landscape shift
7. 7:25 Future outlook and closing

• Prices mentioned: $25 a month, $149 a month and $99 a month
• Who is speaking: Patient

This episode of The Downsize News, hosted by Christopher and Lorraine Durham, covers eight GLP-1 news stories for May 11, 2026. The hosts say they are not doctors and that the video is not medical advice.

1. 0:00 Wegovy Pill Hits 2 MILLION Prescriptions! But Novo Has a Pro
2. 2:38 Novo’s GLP-1 Empire Faces a New Threat
3. 8:42 Foundayo May Be Quieting Food Noise in the Brain
4. 12:30 GLP-1s Are Replacing Bariatric Surgery for Some Patients
5. 16:44 Employers Are Questioning GLP-1 Coverage Costs
6. 19:49 Connecticut Targets Counterfeit Ozempic and Zepbound Sales
7. 23:27 GLP-1 Users Face a New Kind of Weight Stigma
8. 28:16 GLP-1s Linked to Lower AFib Risk in Major Study

• Who is speaking: Patient

This is a weekly Q&A episode from the DOWNSIZED channel, recorded in Paris. Lorraine and Christopher Durham say they are not doctors and are sharing personal experience.

1. 0:00 Food Noise, Weight Regain, and GLP-1 Maintenance Dose Explai
2. 8:34 Weekly Weigh-In Q&A
3. 8:59 Did Surmoun Maintain Include 12.5mg Zepbound?
4. 13:15 What Is Your Maintenance Dose?
5. 14:32 Will GLP-1s Stop Working Over Time?
6. 17:33 Can You Take GLP-1s With a Stomach Ulcer?
7. 18:18 How Long Were You on 5mg Tirzepatide?
8. 20:17 Have Weight Loss Changes Caused Passport or TSA Issues?

• Doses mentioned: 5 mg, 10 mg, 12.5 mg and 15 mg
• Weight loss mentioned: 100 lb
• Side effects mentioned: loose skin or face changes
• Who is speaking: Patient

A patient walks through their time on a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel reviews the topline results Eli Lilly released for retatrutide in its phase three TRIUMPH-1 trial. He says the trial was randomized, double-blind and placebo-controlled, with 2,339 adults who had obesity or overweight and no diabetes.

1. 0:00 30% Weight Loss?! Retatrutide CRUSHES Zepbound
2. 1:34 Triumph 1 Trials
3. 5:42 How It Works
4. 6:18 For Those Who Haven’t Succeeded Yet
5. 7:40 The Real Number
6. 8:34 The Tradeoff
7. 10:59 Not a Replacement. A Portfolio.
8. 15:11 The Top of the Toolbox

• Who is speaking: Patient

This is a live weekly weigh-in recorded on a Royal Caribbean cruise with an audience of about 85 viewers, hosted by Lorraine and Christopher Durham of the channel DOWNSIZED. They say they are not doctors.

1. 0:00 Welcome to Downsized
2. 1:11 Live at Sea
3. 2:46 Christopher Weigh In
4. 4:29 Laraine Weigh In
5. 7:26 Not Doctors Disclaimer
6. 8:26 How to Ask Questions
7. 10:11 Does It Still Work
8. 12:24 Maintenance Surprises

• Doses mentioned: 5 mg, 10 mg, 12.5 mg and 15 mg
• Weight loss mentioned: 50 lb
• Side effects mentioned: constipation, fatigue and low appetite
• Prices mentioned: $30 a month and $79 a month

Lorraine Durham, host of The Downsized, says she has lost over 50 lb on tirzepatide and has kept the weight off with a weekly shot for more than 2 years. She states she is not a doctor and that the video is not medical advice.

1. 0:00 Hair Loss Shock
2. 0:26 Did you have any hair loss?
3. 1:26 Why Shedding Happens
4. 3:09 Rapid Loss Trigger
5. 4:13 Nutrition Deficits
6. 5:37 Is It Permanent
7. 6:30 What To Do Now
8. 6:32 1. Prioritize Protein

• Side effects mentioned: hair loss
• Prices mentioned: $79 a month
• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel reviews the White House announcement about GLP-1 pricing, made with Eli Lilly and Novo Nordisk. He says that as of the video, no prices have changed.

1. 0:00 The $50 GLP-1 Deal: Facts, Feelings & Speculation!
2. 2:25 Details of the Deal
3. 3:00 The Deal
4. 5:26 Timeline and Future Implications
5. 6:24 What's New?
6. 10:13 Open Questions and Concerns
7. 14:12 Conclusion and Call to Action

• Prices mentioned: $50 a month, $350 a month and $499 a month
• Who is speaking: Patient

In this video from the channel DOWNSIZED, hosts Christopher and Lorraine Durham prepare for a 15-day trip that includes a cruise and talk through how they plan to bring their weekly GLP-1 shots.

1. 0:00 Introduction and Welcome
2. 0:06 Discussing Travel Shots
3. 0:30 Medication Management on Vacation
4. 1:03 Traveling with Zepbound and Tirzepatide
5. 1:55 Travel Cases for Shots
6. 2:30 Temperature Concerns and Solutions
7. 6:27 Final Preparations and Tips
8. 9:29 Conclusion and Farewell

• Who is speaking: Patient

A patient talks about stopping a GLP-1 and what came after. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

In this interview on the DOWNSIZED channel, host Lorraine Durham talks with Dr. Michelle Cardel, a nutrition scientist and registered dietitian with 20 years in obesity research. She says she is not a medical doctor.

1. 0:00 Welcome to Downsized
2. 1:05 Meet Dr Cardell
3. 3:11 Why Obesity Research
4. 5:43 Obesity as Disease
5. 6:35 GLP1 Plus Lifestyle
6. 8:00 Eating Enough on GLP1
7. 10:48 Protein Targets Explained
8. 12:41 Shakes Bars and Budget

• Who is speaking: Patient

This is a weekly live Q&A from the Downsized channel, hosted by Lorraine Durham and Christopher Durham. They say they are not doctors and answer from their own experience.

1. 9:37 Food, protein and eating
2. 25:22 Injection technique
3. 34:27 Weigh-in and results
4. 55:01 Stopping and maintenance
5. 1:15:36 Food, protein and eating
6. 1:32:31 Dose change
7. 1:43:18 Weigh-in and results
8. 2:01:11 Food, protein and eating

• Doses mentioned: 10 mg, 12.5 mg and 15 mg
• Weight loss mentioned: 50 lb
• Side effects mentioned: nausea, constipation and fatigue
• Prices mentioned: $79 a month, $100 a month and $50 a month

Christopher Durham of the DOWNSIZED channel reviews the hearing in Eli Lilly's lawsuit against Mochi Health, held in a San Francisco courtroom. He says he is not a doctor or a lawyer and that the video is for information only.

1. 0:00 Intro
2. 1:03 Eli Lilly vs Mochi Health
3. 2:45 Why This Hearing Matters
4. 3:21 Corporate Practice of Medicine
5. 3:53 Judge Berates Lilly’s Lawyers
6. 4:11 Judge's Key Points and Reactions
7. 7:54 Affordability and Patient Impact
8. 9:26 Case Recap and Future Implications

• Weight loss mentioned: 150 lb
• Prices mentioned: $500 a month
• Who is speaking: Patient

A patient talks about food noise, cravings and mood on a GLP-1. Also covers how it works.

• Who is speaking: Patient

Christopher Durham of the DOWNSIZED channel, a patient who says he has used GLP-1 medications since September 2023, looks at the April 2026 news around Eli Lilly's oral GLP-1 Foundayo (orforglipron).

1. 0:00 FDA Approval Whiplash
2. 1:51 What is Foundayo
3. 2:41 Why FDA Wants More Data
4. 4:12 Achieve Four Trial Setup
5. 5:06 Cardio Results Explained
6. 6:25 Mortality Headline Context
7. 7:59 Efficacy And Liver Safety
8. 8:55 Liver Safety

• Doses mentioned: 14.5 mg and 17.2 mg
• Point in the journey: Year 2
• Prices mentioned: $149 a month, $199 a month and $299 a month
• Who is speaking: Patient

This is a live episode of the DOWNSIZED show hosted by Christopher and Lorraine Durham, who say they have lost over 150 pounds together on Zepbound. They open with a news segment on a federal court ruling.

1. 0:00 Introduction
2. 0:14 Compounded semaglutide news
3. 2:29 Court ruling details
4. 5:49 Future of compounding
5. 8:07 Novo Nordisk price offer
6. 9:29 GLP-1 market dynamics
7. 12:25 Cruise updates and Q&A
8. 17:32 Patent news and medication tips

• Weight loss mentioned: 50 lb
• Side effects mentioned: nausea, constipation and fatigue
• Who is speaking: Patient

A patient shares their experience with Ozempic. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

A patient shares their experience with Zepbound. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Patient

This is a weekly live show from the DOWNSIZED channel, hosted by Lorraine Durham, who says she has lost over 50 pounds on compounded GLP-1 medication, and her husband Christopher Durham, who says he has lost over 100 pounds.

1. 4:07 Food, protein and eating
2. 1:13:51 Stopping and maintenance
3. 1:33:01 Dose change
4. 1:53:55 Side effects
5. 2:09:52 Food noise and cravings

• Doses mentioned: 5 mg, 7.5 mg, 10 mg and 15 mg
• Weight loss mentioned: 80 lb
• Side effects mentioned: nausea, vomiting, constipation, fatigue, heartburn or reflux, low appetite and dehydration
• Prices mentioned: $199 a month

A patient talks about food noise, cravings and mood on Zepbound. Also covers stopping and maintenance.

• Who is speaking: Patient

According to the video, the FDA has approved the Wegovy pill from Novo Nordisk as the first and only oral GLP-1 medication cleared for chronic weight management in adults in the United States.

1. 0:00 FDA Approves Wegovy Pill
2. 1:01 Trial Results and Efficacy
3. 2:42 Rapid Review and Competition
4. 4:23 Pricing and Coverage Challenges
5. 5:49 Market Impact and Outlook
6. 6:56 Live Show and Conclusion

• Doses mentioned: 1.5 mg
• Prices mentioned: $149 a month
• Who is speaking: Patient

This episode of the weekly Downsized News, recorded February 16, 2026, covers eight GLP-1 stories. The hosts say they are not doctors and that the video is not medical advice.

1. 0:00 36% of Wegovy Pill Are New to GLP-1s! DOWNSIZED NEWS
2. 0:24 Downsized News
3. 2:13 36% of Wegovy Pill Users Are Brand New to GLP-1s
4. 6:05 Why Lilly Is Stockpiling $1.5 Billion Ahead of Its Pill Laun
5. 9:11 FDA Says Novo’s Wegovy Pill Ad Is Misleading
6. 12:02 AstraZeneca Enters the Oral GLP-1 Race
7. 14:16 Are GLP-1 Users at Risk of a “Pirate Disease”?
8. 17:30 McDonald’s Joins the GLP-1 Menu Shift

• Side effects mentioned: muscle loss
• Who is speaking: Patient

This is a weekly live Q&A from the hosts of Downsized, a couple who say they are patients and not doctors. They say they have lost over 100 pounds (Christopher) and 50 pounds (Lorraine) and kept it off.

1. 15:20 Alcohol
2. 23:14 Weigh-in and results
3. 36:45 Cost and insurance
4. 48:34 Side effects
5. 1:07:05 Exercise and strength
6. 1:21:20 Dose change
7. 1:37:02 Stopping and maintenance
8. 1:53:46 Weigh-in and results

• Doses mentioned: 2.5 mg, 5 mg, 9 mg and 10 mg
• Weight loss mentioned: 18 lb
• Side effects mentioned: nausea, vomiting, constipation, diarrhea, fatigue, headache, hair loss and dehydration
• Prices mentioned: $90 a month and $99 a month

Lorraine Durham, who runs the DOWNSIZED channel, films herself giving her weekly injection of compounded tirzepatide. She says she began her weight loss on September 29, 2023, reached her goal weight in about two and a half years, and now takes 10 mg weekly during maintenance.

1. 0:00 Introduction and background
2. 0:56 Preparation and supplies
3. 1:58 Choosing an injection site
4. 3:23 Drawing the medication
5. 5:34 Administering the injection
6. 7:09 Storage and service details

• Doses mentioned: 10 mg
• Side effects mentioned: loose skin or face changes
• Prices mentioned: $79 a month and $199 a month
• Who is speaking: Patient

A patient shares their experience with a GLP-1. It has no captions we could read, so this is drawn from its title and description.

1. 0:00 Introduction to GLP-1 Weight Loss Medications
2. 0:11 Meet Laraine: A Weight Loss Journey on GLP-1
3. 0:31 Understanding Tirsepatide, Mounjaro and Zepbound
4. 1:14 The Struggle with Traditional Weight Loss Methods
5. 2:00 Obesity: Recognizing it as a Chronic Disease
6. 2:30 Choosing Compounded Medication: My Story
7. 3:04 The Logistics of Getting Compounded Tirzepatide
8. 5:42 Why Choose Compounded Medication Over Retail?

• Who is speaking: Patient

Rachel Reynolds, a skincare business owner who turns 49 in the video, tells host Lorraine Durham how she lost weight on Rybelsus, the pill form of semaglutide.

1. 0:00 Welcome to The Downsized Dish
2. 0:51 Rachael's Weight Loss Journey Begins
3. 1:57 Transitioning to Entrepreneurship and Its Challenges
4. 3:35 Discovering GLP-1 Medications and the Path to Weight Loss
5. 5:51 The Surprising Impact on Alcohol Consumption
6. 11:25 Exploring the Benefits and Struggles of GLP-1 Medications
7. 18:23 Navigating Food Choices and Lifestyle Changes
8. 22:32 Reflections and Advice for Others on the Weight Loss Journey

• Prices mentioned: $25 a month
• Who is speaking: Patient

In this episode of The Downsized Dish, host Lorraine Durham interviews Joe, a Mounjaro user from Nottingham in the UK who runs the channel Joe's Sleep and Slim Down Journey.

1. 0:00 Introduction to the Downsized Dish
2. 1:10 Meet Jo: A Weight Loss Journey
3. 2:26 Jo's Health Struggles and Transformation
4. 5:45 The Role of Mounjaro and CPAP in Jo's Recovery
5. 7:58 Jo's Life Changes and Future Aspirations
6. 20:26 Managing Mounjaro Dosages and Side Effects
7. 28:13 Navigating the Cost and Accessibility of Mounjaro
8. 34:18 Discussing Medication Dosage and Costs

• Doses mentioned: 10 mg and 15 mg
• Weight loss mentioned: 80 lb, in the title
• Side effects mentioned: constipation
• Who is speaking: Patient

In this Downsized Dish interview, host Lorraine Durham talks with Reagan, a 50-year-old mother of three from Missouri who runs a rodeo production company with her family. She says her highest weight was 232 lbs and she started tirzepatide in November 2024 at 213 lbs.

1. 0:00 Welcome
2. 1:04 Meet Regan and Her Stats
3. 2:29 Finding Maintenance Weight
4. 4:03 Weight Gain and Hormones
5. 5:16 Before and After Photos
6. 7:10 Food Noise and Tracking
7. 8:53 Starting GLP-1 via Groupon
8. 11:13 Side Effects and Sensitivity

• Weight loss mentioned: 67 lb, in the title
• Who is speaking: Patient

In this video, Christopher Durham, who hosts the channel DOWNSIZED, describes what he calls food noise: constant thoughts about what to eat, when to eat and how much to eat.

1. 0:00 The constant food noise
2. 1:26 My weight loss journey
3. 1:52 Understanding food noise
4. 2:55 How GLP-1 medications work
5. 3:57 Science and final thoughts

• Who is speaking: Patient

In this 5:50 video from the DOWNSIZED channel, Laraine Durham describes the side effects she has had while taking tirzepatide, which she says is sold as Mounjaro and Zepbound, and what she does about each one.

1. 0:00 Welcome to The Downsized
2. 0:14 Navigating Side Effects
3. 0:31 Fatigue: Managing Energy Levels on Shot Days
4. 1:03 Hair Loss: Prevention and Care
5. 1:27 Combating Heartburn and Sulfur Burps
6. 1:50 Dealing with Nausea and Dietary Adjustments
7. 2:30 Constipation: Strategies for Relief
8. 5:33 Final Thoughts and Disclaimer

• Side effects mentioned: nausea, vomiting, constipation, fatigue and heartburn or reflux
• Who is speaking: Patient

A patient talks about food noise, cravings and mood on Zepbound. They report losing 94 lb, as the title says.

• Weight loss mentioned: 94 lb, in the title
• Who is speaking: Patient

In this video from the DOWNSIZED channel, host Christopher Durham reports on a new court document in the case between the Outsourcing Facilities Association (OFA) and the FDA over compounded tirzepatide.

1. 0:00 Introduction and Overview
2. 0:17 Background on the Legal Battle
3. 0:58 Personal Journey with GLP-1 Medications
4. 1:35 Key Arguments in the OFA vs. FDA Case
5. 3:04 Recent Court Developments
6. 4:27 Judge Mark T. Pittman's Influence
7. 5:52 Potential Outcomes and Implications
8. 6:22 Community Engagement and Conclusion

• Who is speaking: Patient

In this live news update, Christopher Durham of the DOWNSIZED channel says Novo Nordisk has asked the FDA to put compounded semaglutide on the demonstrable difficulties for compounding (DDC) list.

1. 0:00 Introduction and context
2. 2:06 Novo Nordisk petition
3. 4:24 Timeline for FDA review
4. 5:36 Safety and quality concerns
5. 8:21 Impact on patients
6. 10:07 Risks of do-it-yourself
7. 11:58 Navigating future shortages
8. 14:08 Cost and supply discussion

• Who is speaking: Patient