Dr. Kevin Joseph, DO

Dr. Kevin Joseph, an internal medicine physician in Upstate New York, looks at whether the injection site matters for GLP-1 weight loss and appetite suppression.

1. 0:00 Intro
2. 0:30 Mechanism of Action
3. 1:33 Where to inject
4. 2:37 The study
5. 4:19 The results
6. 6:27 Adverse results
7. 7:27 My personal experience
8. 10:34 Final thoughts

• Side effects mentioned: nausea, vomiting, constipation, fatigue and low appetite
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, who says he specializes in obesity medicine and peptide therapy, argues that retatrutide should not be judged only by weight loss. He describes it as a once-weekly injection from Eli Lilly that activates three receptors: GLP-1, GIP and glucagon.

1. 0:00 The case for retatrutide
2. 1:00 Mechanism of action
3. 2:10 How the three switches work
4. 4:08 Weight loss clinical results
5. 5:14 Impact on liver health
6. 8:31 Joint health and mobility
7. 10:11 Cardiovascular and lipid data
8. 11:12 Kidney and respiratory health

• Doses mentioned: 1 mg, 4 mg and 9 mg
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, a physician who says he has lost over 150 lb, lists seven things he would do differently if he were starting GLP-1 treatment again. He says some are mistakes he made himself and others are patterns he has seen in his patients.

1. 0:00 GLP-1 journey introduction
2. 0:28 Baseline data and monitoring
3. 1:37 Resistance training
4. 2:23 Protein intake importance
5. 3:10 Managing side effects
6. 3:35 Action over perfection
7. 4:20 Peptide usage strategy
8. 5:13 Psychological health

• Point in the journey: Year 2
• Side effects mentioned: nausea, constipation and muscle loss
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, an internal medicine physician in upstate New York, describes five mistakes he says he commonly sees in patients new to GLP-1 agonist therapy. He says he has lost over 140 lbs on GLP-1 agonist and peptide therapy.

1. 0:00 Introduction
2. 0:17 Wrong injection site
3. 2:21 Too many calories
4. 3:08 Not eating enough
5. 5:21 Electrolytes
6. 6:31 Increasing dose too soon
7. 7:39 Final thoughts

• Doses mentioned: 2.5 mg
• Side effects mentioned: fatigue, muscle loss, low appetite and dehydration
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, an internal medicine physician and medical director, says more of his patients are getting retatrutide through gray market sources, medical spas and compounding pharmacies. He made the video to explain seven things to avoid or watch closely while taking it.

1. 0:00 Intro
2. 1:25 Corticosteroids
3. 7:00 Overactive thyroid/thyroid medications
4. 9:38 Insulin secretagogues
5. 11:45 Phenteramine
6. 14:18 Over the counter stimulants
7. 16:20 Alcohol use
8. 17:30 Diuretics

• Side effects mentioned: dizziness, dehydration and pancreatitis
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

A clinician (DO) explains how tirzepatide works and what the evidence says. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, who says he lost over 150 lb on GLP-1 medications himself, explains why weight loss stalls on semaglutide or tirzepatide and what he suggests doing about it.

1. 0:00 Intro
2. 1:45 What's actually happening in your body when it plateaus?
3. 3:16 1: Metabolism. Your metabolism starts to turn against you.
4. 4:24 Fix: Strategic diet break aka metabolic rest week.
5. 6:11 2: Muscle. Muscle loss slows everything down.
6. 7:24 Fix: Lift weights and eat more protein.
7. 9:12 3: Hormones. The hunger hormones counterattack.
8. 10:33 Fix: Reset your hormones.

• Side effects mentioned: muscle loss
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, a board-certified internal medicine physician and medical director, says many new patients come to him after severe side effects on GLP-1 medications.

1. 0:00 Introduction
2. 2:00 Anhedonia
3. 3:45 Allodynia
4. 5:15 Nausea
5. 7:31 Extreme fatigue
6. 9:28 Insomnia
7. 10:38 Not eating enough
8. 12:17 Dehydration

• Doses mentioned: 2.4 mg
• Side effects mentioned: nausea, vomiting, fatigue, dizziness and dehydration
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

In this short video, Dr. Kevin Joseph, DO, lists five foods and habits he recommends avoiding for people taking GLP-1 agonists such as Ozempic or Mounjaro. He says his goal is to reduce side effects and support weight loss.

1. 0:00 Intro
2. 0:17 Red meat
3. 1:35 Friend and Greasy Foods
4. 2:20 Artificial Sweeteners
5. 3:06 Cruciferous Vegetables
6. 4:05 Large Volume Meals
7. 4:50 Final Thoughts

• Side effects mentioned: nausea, vomiting, heartburn or reflux and bloating
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, a physician, says the biggest mistake in his weight loss on Mounjaro was not doing heavy resistance training from the start. He reports losing over 140 pounds and says the change has affected his health, his relationships and how he sees the world.

1. 0:00 My GLP-1 weight loss journey
2. 1:08 Muscle loss risks
3. 3:38 GLP-1s and extreme restriction
4. 5:07 My mistake with cardio
5. 6:24 Importance of resistance
6. 8:27 GLP-1s vs bariatric surgery
7. 10:27 Actionable advice for you

• Weight loss mentioned: 140 lb, in the title
• Side effects mentioned: fatigue and muscle loss
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, a physician who also describes himself as living with chronic obesity and an eating disorder, shares an update on his personal plan. He says he has lost over 150 lbs and held around 205 lbs on 1.25 mg of tirzepatide every 5 days, which controlled his food noise.

1. 0:00 Intro
2. 0:25 Health Goals
3. 4:16 Growth Hormone
4. 7:09 Glow Protocol
5. 8:38 Current peptide schedule
6. 9:47 My peptide stack

• Doses mentioned: 2.5 mg
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, DO, goes through five side effects he says he sees most often in patients taking Ozempic or Mounjaro, several of which he has also had himself. For each one he explains what he believes causes it and what he suggests to prevent or treat it.

1. 0:00 Intro
2. 0:15 Constipation
3. 2:45 Diarrhea
4. 5:50 Fatigue
5. 9:38 Insomnia
6. 10:55 Nausea

• Doses mentioned: 2.5 mg and 5 mg
• Side effects mentioned: nausea, constipation, diarrhea, fatigue and dehydration
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, DO, explains how he approaches maintenance dosing once someone on a GLP-1 medication reaches a goal weight.

1. 0:00 Post-weight loss options
2. 1:00 Clinical trials and risks
3. 3:12 Finding your ideal dose
4. 7:57 Personal maintenance regimen

• Doses mentioned: 5 mg and 10 mg
• Side effects mentioned: low appetite
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, an internal medicine physician in Upstate New York, shares five tips for people starting a GLP-1 agonist such as Ozempic or Mounjaro. He says he has lost over 140 lbs on a GLP-1 agonist himself, and that the tips draw partly on feedback from his patients.

1. 0:00 Intro
2. 0:50 Find a good healthcare provider
3. 2:20 Go low and go slow
4. 6:03 Be prepared
5. 9:45 Listen to yourself
6. 12:33 Summary

• Side effects mentioned: nausea, vomiting, diarrhea and dehydration
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

In this short video, Dr. Kevin Joseph, a physician, explains why hair thinning can show up for people taking GLP-1 medications such as Ozempic or Mounjaro.

1. 0:00 Intro
2. 1:00 Hair growth cycle
3. 2:32 Causes of hair loss and how to correct it
4. 4:30 Why supplements don't work
5. 4:45 Closing thoughts

• Side effects mentioned: hair loss
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, a doctor of osteopathic medicine, uses this follow-up video to explain where he stands on compounding pharmacies, gray market peptides, and the pricing of GLP-1 medications.

1. 0:00 Intro
2. 3:10 The Real Economics
3. 5:34 Compounding
4. 7:23 Gray Market
5. 10:03 Conclusion

• Point in the journey: Year 3
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

A clinician (DO) looks at injection site reactions on a GLP-1. It has no captions we could read, so this is drawn from its title and description.

• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph, DO, explains when he thinks a person on a GLP-1 medication should raise or lower their dose.

1. 0:00 Intro
2. 0:54 Signs to Increase Dose
3. 4:58 Signs to Decrease Dose
4. 6:40 Concluding Thoughts

• Side effects mentioned: nausea, vomiting and fatigue
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)

Dr. Kevin Joseph says orforglipron is the first oral small molecule GLP-1 receptor agonist to get this far in clinical trials.

1. 0:19 Injection technique
2. 1:49 The trials
3. 2:08 Dose change
4. 3:09 The trials

• Doses mentioned: 7 mg and 14 mg
• Who is speaking: Clinician, DO (Dr. Kevin Joseph)