GLP-1 Drug Comparison Builder: Compare Any 2-3 Medications
Pick any two or three GLP-1 drugs below and we'll build a side-by-side comparison instantly — average weight loss, monthly cost, FDA status, dosing frequency, and the real pros and cons of each. Updated April 2026.
Medically reviewed by Dr. A. Goher, MD - Last updated April 6, 2026
Pick 2-3 drugs to compare
2 of 3 selected
Side-by-Side Comparison
| Feature | Wegovy | Zepbound |
|---|---|---|
| Manufacturer | Novo Nordisk | Eli Lilly |
| Generic name | Semaglutide | Tirzepatide |
| Type | GLP-1 | Dual GIP/GLP-1 |
| Form | Weekly injection | Weekly injection |
| Frequency | Weekly | Weekly |
| Avg. weight loss | 15-17% | 20-22% Winner - Most weight loss |
| Monthly list price | $1,349 | $1,060 Winner - Lowest cost |
| With insurance | $25-$200 typical copay | Varies by plan |
| FDA approval | Weight loss | Weight loss |
| Year approved | 2021 | 2023 |
- Manufacturer
- Novo Nordisk
- Generic name
- Semaglutide
- Type
- GLP-1
- Form
- Weekly injection
- Frequency
- Weekly
- Year approved
- 2021
- Avg. weight loss
- 15-17%
- Monthly list price
- $1,349
- FDA approval
- Weight loss
- With insurance
- $25-$200 typical copay
- Manufacturer
- Eli Lilly
- Generic name
- Tirzepatide
- Type
- Dual GIP/GLP-1
- Form
- Weekly injection
- Frequency
- Weekly
- Year approved
- 2023
- Avg. weight loss
- 20-22%Winner - Most weight loss
- Monthly list price
- $1,060Winner - Lowest cost
- FDA approval
- Weight loss
- With insurance
- Varies by plan
Key Pros and Cons
Wegovy
Semaglutide - Novo Nordisk
Pros
- FDA-approved specifically for chronic weight management
- Also approved for cardiovascular risk reduction
- Oral pill version launched January 2026
Cons
- Highest list price of any semaglutide product
- Still sees periodic shortages at higher doses
- Commercial insurance weight-loss coverage is uneven
Zepbound
Tirzepatide - Eli Lilly
Pros
- Highest average weight loss of any approved GLP-1
- FDA-approved for chronic weight management
- LillyDirect self-pay vials at reduced cost
Cons
- Stronger GI side effects than semaglutide
- Insurance coverage still inconsistent
- More expensive than Mounjaro despite same ingredient
Best for Wegovy, Zepbound
For maximum weight loss, Zepbound leads with an average of 20-22%. Zepbound is the lowest list price at $1,060 per month. Wegovy, Zepbound are FDA-approved specifically for weight loss, which matters for insurance coverage.
Next steps
Picked a drug? These guides help you get it affordably.
Disclaimer: This comparison tool is for educational purposes only and does not constitute medical advice. Average weight loss values reflect published clinical trial ranges and may not represent individual results. Pricing reflects manufacturer list prices and typical commercial insurance copays as of April 2026 and can change without notice. Always consult a licensed clinician before starting, stopping, or switching any GLP-1 medication.