Zepbound Dosage: The Full Titration Schedule & Dose Chart
Zepbound (Tirzepatide) is taken as a once-weekly subcutaneous injection, and you don't start at the full dose — you titrate up step by step to limit side effects. Here is the complete schedule, the dose chart, where to inject it, and what to do if you miss a dose.
Zepbound Dose Chart & Titration Schedule
The standard step-up schedule. Your prescriber may move faster or slower based on how you tolerate each dose.
| Step | Dose | When | Notes |
|---|---|---|---|
| 1 | 2.5 mg / week | Weeks 1–4 | Starter dose |
| 2 | 5 mg / week | Weeks 5–8 | — |
| 3 | 7.5 mg / week | Weeks 9–12 | Increase by 2.5 mg in steps of 4+ weeks as needed |
| 4 | 10 mg / week | Weeks 13–16 | — |
| 5 | 12.5 mg / week | Weeks 17–20 | — |
| 6 | 15 mg / week | Week 21 onward | Maximum dose |
Zepbound Injection Sites & How to Inject
Zepbound is injected under the skin. Rotate between these sites — use a different spot each time so the skin has time to recover.
Abdomen (stay 2 inches clear of the navel)
Front of the thigh
Back of the upper arm
Quick injection tips
- Inject the same day each week and set a reminder so doses stay evenly spaced.
- Let a refrigerated pen sit a few minutes to reach room temperature — it stings less.
- Rotate sites and spots; don't inject into tender, bruised, or scarred skin.
- Use a fresh needle every time and dispose of it in a sharps container.
Missed a Dose of Zepbound?
If your next dose is 4+ days away, take the missed dose as soon as you remember. If it is sooner, skip it and resume your normal weekly schedule.
Get Tirzepatide with the dosing handled for you
Licensed telehealth providers prescribe Tirzepatide, set your titration schedule, and ship each dose to your door — usually for far less than the ~$1,060/month brand price.
Zepbound Dosing FAQ
What is the starting dose of Zepbound?
Zepbound starts at 2.5 mg once weekly. This low starter dose is meant to build tolerance and limit side effects — it is not the full weight-loss dose. You step up gradually under your prescriber's guidance until you reach a maintenance dose of 5, 10, or 15 mg once weekly.
How long does it take to titrate up to the full Zepbound dose?
Most patients reach the maintenance dose of 5, 10, or 15 mg once weekly after following the titration schedule above — typically a couple of months of step-ups. Your prescriber may move slower if you have side effects. The maximum dose is 15 mg once weekly.
Where do I inject Zepbound?
Zepbound is given as a once-weekly subcutaneous injection. Rotate between approved sites — abdomen (stay 2 inches clear of the navel), front of the thigh, back of the upper arm — using a different spot each time to protect the skin.
What if I miss a dose of Zepbound?
If your next dose is 4+ days away, take the missed dose as soon as you remember. If it is sooner, skip it and resume your normal weekly schedule.
Where can I get Zepbound or its Tirzepatide for less?
Brand Zepbound lists around $1,060/month. The same molecule (Tirzepatide) is available through licensed telehealth providers — often from a fraction of that price, with the dose titration managed for you. Compare verified providers on our cheapest-providers page.
Disclaimer: This dosing information is educational and reflects standard manufacturer schedules. Your actual dose and titration must be set by your prescriber based on your health, tolerance, and response. Never adjust your dose on your own. Always follow the instructions that come with your medication.