Yucca Health vs TMates: Which GLP-1 Program Is Better? (2026)
We put Yucca Health and TMates head-to-head — what you actually pay each month, which GLP-1 medications you can get, the level of clinician support, and where each one wins — so you can pick the cheaper, better-fit weight loss program in minutes.
Quick Verdict
We recommend Yucca Health
Between these two providers, Yucca Health is our pick for most users. It offers a higher overall rating (9.2 vs 7.8), more affordable pricing, availability in all 50 states. That said, TMates may be the better fit if you are looking for insured patients who want a coached glp-1 program with a few medication choices.
Yucca Health scores 9.2/10 in our independent evaluation at $146/month, while TMates scores 7.8/10 at $199/month. Both programs connect you with a licensed physician and deliver medication straight to your door. Each score weighs five things: safety and medical oversight (30%), pricing transparency (25%), value for money (20%), quality of clinical support (15%), and how fast you can get started (10%). We build these comparisons ourselves — no provider buys a better rating or a higher spot. Pricing checked April 2026.
Side-by-Side Comparison
| Feature | Yucca Health | TMates |
|---|---|---|
| Monthly Price | $146 | $199 |
| Rating | 9.2 / 10 | 7.8 / 10 |
| Medication Type | Compounded Only | Compounded Only |
| Insurance Accepted | No | Yes |
| States Available | All 50 states | 45 states |
| Consultation Fee | Free | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | U.S.-licensed doctors (Dr. Wasef, Dr. Sakla) guiding your care with reviews inside 24 hours | Licensed clinicians paired with text-message coaching and digital check-ins |
Figures show entry-level cash prices before any insurance. What you ultimately pay can change with your plan and the specific medication. Last checked April 2026.
Yucca Health: Detailed Look
Yucca Health
A LegitScript-verified GLP-1 service with doctors you can name and pay-over-time options
Pros
- Both the pharmacy and telehealth side carry LegitScript verification
- More than 1,000 verified patient reviews put it at 4.6 out of 5 on Trustpilot
- You'll know your doctors by name: Dr. Michael Wasef, MD and Dr. Andrew Sakla, DO
- Spread the cost over time through Klarna, Affirm, or Afterpay
Cons
- Locking in the lowest price means signing on for six months
- Everything's compounded here — no brand-name versions offered
People wanting a LegitScript-verified provider with real patient reviews and pay-over-time options
TMates: Detailed Look
TMates
A GLP-1 weight loss program you can put through most major insurance plans
Pros
- Among the rare GLP-1 services that will actually take major insurance
- A single flat rate wraps in meds, visits, coaching, and delivery
- Text-based coaching and digital check-ins run around the clock
- Phentermine is available for those who aren't GLP-1 candidates
Cons
- It's a younger platform, so independent reviews remain sparse
- You'll need to enroll before the full program details are confirmed
Insured patients who want a coached GLP-1 program with a few medication choices
How to Decide Between Them
There is no single winner for everyone — it comes down to what matters most to you. Match your priority to the scenarios below to see which provider fits:
Go with Yucca Health at $146/month. Six-month semaglutide plan at $146/mo, tirzepatide $258/mo. Pay via Klarna, Affirm, or Afterpay..
Yucca Health has the edge with a 9.2 rating.
TMates accepts insurance, which can significantly reduce your out-of-pocket cost.
Compare their support: Yucca Health offers u.s.-licensed doctors (dr. wasef, dr. sakla) guiding your care with reviews inside 24 hours, while TMates provides licensed clinicians paired with text-message coaching and digital check-ins.
TMates at $199/month may offer features that justify the premium.
Frequently Asked Questions
Is Yucca Health better than TMates?
Yucca Health has a 9.2 rating while TMates has a 7.8 rating. The better choice depends on your priorities — Yucca Health is best for people wanting a legitscript-verified provider with real patient reviews and pay-over-time options, while TMates is best for insured patients who want a coached glp-1 program with a few medication choices.
How much does Yucca Health cost compared to TMates?
Yucca Health starts at $146/month (six-month semaglutide plan at $146/mo, tirzepatide $258/mo. pay via klarna, affirm, or afterpay.), while TMates starts at $199/month (semaglutide at $199/mo, tirzepatide at $297/mo).
Do Yucca Health and TMates accept insurance?
Yucca Health does not accept insurance. TMates accepts insurance.
Which GLP-1 medications does Yucca Health offer vs TMates?
Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+. TMates offers Compounded Semaglutide, Compounded Tirzepatide, Phentermine.
Can I cancel Yucca Health or TMates at any time?
Yucca Health may have cancellation restrictions. TMates also allows cancel anytime.
Are Yucca Health and TMates available in my state?
Yucca Health is available in all 50 states. TMates is available in 45 states.
Not sure Yucca Health or TMates is right for you?
Take our 6-question quiz and we'll point you to the program that fits your budget and goals best.