Yucca Health vs SynergyRx: Which GLP-1 Program Is Better? (2026)
We put Yucca Health and SynergyRx head-to-head — what you actually pay each month, which GLP-1 medications you can get, the level of clinician support, and where each one wins — so you can pick the cheaper, better-fit weight loss program in minutes.
Quick Verdict
We recommend Yucca Health
Between these two providers, Yucca Health is our pick for most users. It offers a higher overall rating (9.2 vs 5.6), more affordable pricing, availability in all 50 states. That said, SynergyRx may be the better fit if you are looking for people who want one predictable bundled price and support they can reach at any hour.
Yucca Health scores 9.2/10 in our independent evaluation at $146/month, while SynergyRx scores 5.6/10 at $200/month. Both programs connect you with a licensed physician and deliver medication straight to your door. Each score weighs five things: safety and medical oversight (30%), pricing transparency (25%), value for money (20%), quality of clinical support (15%), and how fast you can get started (10%). We build these comparisons ourselves — no provider buys a better rating or a higher spot. Pricing checked April 2026.
Side-by-Side Comparison
| Feature | Yucca Health | SynergyRx |
|---|---|---|
| Monthly Price | $146 | $200 |
| Rating | 9.2 / 10 | 5.6 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | All 50 states | 45 states |
| Consultation Fee | Free | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | U.S.-licensed doctors (Dr. Wasef, Dr. Sakla) guiding your care with reviews inside 24 hours | Licensed providers reachable by message any hour, with no limit on check-ins |
Figures show entry-level cash prices before any insurance. What you ultimately pay can change with your plan and the specific medication. Last checked April 2026.
Yucca Health: Detailed Look
Yucca Health
A LegitScript-verified GLP-1 service with doctors you can name and pay-over-time options
Pros
- Both the pharmacy and telehealth side carry LegitScript verification
- More than 1,000 verified patient reviews put it at 4.6 out of 5 on Trustpilot
- You'll know your doctors by name: Dr. Michael Wasef, MD and Dr. Andrew Sakla, DO
- Spread the cost over time through Klarna, Affirm, or Afterpay
Cons
- Locking in the lowest price means signing on for six months
- Everything's compounded here — no brand-name versions offered
People wanting a LegitScript-verified provider with real patient reviews and pay-over-time options
SynergyRx: Detailed Look
SynergyRx
All-in-one GLP-1 plans that bundle round-the-clock support and skip surprise charges
Pros
- One bundled rate covers it all, with no charge for messaging or dose changes
- Every order ships expedited at no extra cost
- Reach support at any hour and message as much as you want
- Works with several certified pharmacies to keep supply steady
Cons
- At $200/mo, the entry price is middle-of-the-pack for compounded semaglutide
- Coverage doesn't stretch to every state
People who want one predictable bundled price and support they can reach at any hour
How to Decide Between Them
There is no single winner for everyone — it comes down to what matters most to you. Match your priority to the scenarios below to see which provider fits:
Go with Yucca Health at $146/month. Six-month semaglutide plan at $146/mo, tirzepatide $258/mo. Pay via Klarna, Affirm, or Afterpay..
Yucca Health has the edge with a 9.2 rating.
Yucca Health focuses on compounded medications at a lower price point.
Compare their support: Yucca Health offers u.s.-licensed doctors (dr. wasef, dr. sakla) guiding your care with reviews inside 24 hours, while SynergyRx provides licensed providers reachable by message any hour, with no limit on check-ins.
SynergyRx at $200/month may offer features that justify the premium.
Frequently Asked Questions
Is Yucca Health better than SynergyRx?
Yucca Health has a 9.2 rating while SynergyRx has a 5.6 rating. The better choice depends on your priorities — Yucca Health is best for people wanting a legitscript-verified provider with real patient reviews and pay-over-time options, while SynergyRx is best for people who want one predictable bundled price and support they can reach at any hour.
How much does Yucca Health cost compared to SynergyRx?
Yucca Health starts at $146/month (six-month semaglutide plan at $146/mo, tirzepatide $258/mo. pay via klarna, affirm, or afterpay.), while SynergyRx starts at $200/month (semaglutide comes in at $200/mo, with tirzepatide ranging from $299 to $347/mo).
Do Yucca Health and SynergyRx accept insurance?
Yucca Health does not accept insurance. SynergyRx does not accept insurance.
Which GLP-1 medications does Yucca Health offer vs SynergyRx?
Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+. SynergyRx offers Compounded Semaglutide, Compounded Tirzepatide, Ozempic, Wegovy, Mounjaro.
Can I cancel Yucca Health or SynergyRx at any time?
Yucca Health may have cancellation restrictions. SynergyRx also allows cancel anytime.
Are Yucca Health and SynergyRx available in my state?
Yucca Health is available in all 50 states. SynergyRx is available in 45 states.
Not sure Yucca Health or SynergyRx is right for you?
Take our 6-question quiz and we'll point you to the program that fits your budget and goals best.