TMates vs Sesame Care: Which GLP-1 Program Is Better? (2026)
We put TMates and Sesame Care head-to-head — what you actually pay each month, which GLP-1 medications you can get, the level of clinician support, and where each one wins — so you can pick the cheaper, better-fit weight loss program in minutes.
Quick Verdict
We recommend TMates
Between these two providers, TMates is our pick for most users. It offers a higher overall rating (7.8 vs 7.2), more affordable pricing. That said, Sesame Care may be the better fit if you are looking for insured patients chasing cheap doctor visits, keeping in mind the medication is billed separately.
TMates scores 7.8/10 in our independent evaluation at $199/month, while Sesame Care scores 7.2/10 at $225/month. Both programs connect you with a licensed physician and deliver medication straight to your door. TMates accepts insurance, which can significantly reduce costs. Each score weighs five things: safety and medical oversight (30%), pricing transparency (25%), value for money (20%), quality of clinical support (15%), and how fast you can get started (10%). We build these comparisons ourselves — no provider buys a better rating or a higher spot. Pricing checked April 2026.
Side-by-Side Comparison
| Feature | TMates | Sesame Care |
|---|---|---|
| Monthly Price | $199 | $225 |
| Rating | 7.8 / 10 | 7.2 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | Yes | Yes |
| States Available | 45 states | All 50 states |
| Consultation Fee | Included | $25-75 |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed clinicians paired with text-message coaching and digital check-ins | Licensed physicians booked one visit at a time |
Figures show entry-level cash prices before any insurance. What you ultimately pay can change with your plan and the specific medication. Last checked April 2026.
TMates: Detailed Look
TMates
A GLP-1 weight loss program you can put through most major insurance plans
Pros
- Among the rare GLP-1 services that will actually take major insurance
- A single flat rate wraps in meds, visits, coaching, and delivery
- Text-based coaching and digital check-ins run around the clock
- Phentermine is available for those who aren't GLP-1 candidates
Cons
- It's a younger platform, so independent reviews remain sparse
- You'll need to enroll before the full program details are confirmed
Insured patients who want a coached GLP-1 program with a few medication choices
Sesame Care: Detailed Look
Sesame Care
A low-cost telehealth marketplace that matches you with a doctor for as little as $25
Pros
- About the cheapest consult you'll find, with visits opening at $25
- Writes scripts for FDA-approved brand-name drugs
- Clear pay-per-visit pricing and nothing to subscribe to
- A broad bench of licensed physicians spanning all 50 states
Cons
- What the drug costs is billed on its own, apart from the visit fee
- No compounded route here — it's brand-name only, so the drug runs pricier
Insured patients chasing cheap doctor visits, keeping in mind the medication is billed separately
How to Decide Between Them
There is no single winner for everyone — it comes down to what matters most to you. Match your priority to the scenarios below to see which provider fits:
Go with TMates at $199/month. Semaglutide at $199/mo, tirzepatide at $297/mo.
TMates has the edge with a 7.8 rating.
TMates focuses on compounded medications at a lower price point.
Compare their support: TMates offers licensed clinicians paired with text-message coaching and digital check-ins, while Sesame Care provides licensed physicians booked one visit at a time.
Sesame Care at $225/month may offer features that justify the premium.
Frequently Asked Questions
Is TMates better than Sesame Care?
TMates has a 7.8 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — TMates is best for insured patients who want a coached glp-1 program with a few medication choices, while Sesame Care is best for insured patients chasing cheap doctor visits, keeping in mind the medication is billed separately.
How much does TMates cost compared to Sesame Care?
TMates starts at $199/month (semaglutide at $199/mo, tirzepatide at $297/mo), while Sesame Care starts at $225/month (visits run $25-75, and the medication is billed separately at pharmacy rates ($200-1,400/mo). with insurance savings cards the total opens around $225/mo. the drug is not part of the visit fee.).
Do TMates and Sesame Care accept insurance?
TMates accepts insurance. Sesame Care accepts insurance.
Which GLP-1 medications does TMates offer vs Sesame Care?
TMates offers Compounded Semaglutide, Compounded Tirzepatide, Phentermine. Sesame Care offers Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus.
Can I cancel TMates or Sesame Care at any time?
TMates allows cancel anytime. Sesame Care also allows cancel anytime.
Are TMates and Sesame Care available in my state?
TMates is available in 45 states. Sesame Care is available in all 50 states.
Not sure TMates or Sesame Care is right for you?
Take our 6-question quiz and we'll point you to the program that fits your budget and goals best.