Enhance MD vs Trimi: Which GLP-1 Program Is Better? (2026)
We put Enhance MD and Trimi head-to-head — what you actually pay each month, which GLP-1 medications you can get, the level of clinician support, and where each one wins — so you can pick the cheaper, better-fit weight loss program in minutes.
Quick Verdict
We recommend Enhance MD
Between these two providers, Enhance MD is our pick for most users. It offers a higher overall rating (8.3 vs 8.1), both brand-name and compounded medication options. That said, Trimi may be the better fit if you are looking for self-pay patients who want a flat, predictable price as their dose increases.
Enhance MD scores 8.3/10 in our independent evaluation at $249/month, while Trimi scores 8.1/10 at $99/month. Both programs connect you with a licensed physician and deliver medication straight to your door. Each score weighs five things: safety and medical oversight (30%), pricing transparency (25%), value for money (20%), quality of clinical support (15%), and how fast you can get started (10%). We build these comparisons ourselves — no provider buys a better rating or a higher spot. Pricing checked April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | Trimi |
|---|---|---|
| Monthly Price | $249 | $99 |
| Rating | 8.3 / 10 | 8.1 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | Free |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified doctors | US-licensed clinicians via Arora Health |
Figures show entry-level cash prices before any insurance. What you ultimately pay can change with your plan and the specific medication. Last checked April 2026.
Enhance MD: Detailed Look
Enhance MD
Doctor-directed weight management that also offers NAD+ add-ons
Pros
- Wallet-friendly way in, with pricing that begins at $115/month
- An uncommon NAD+ therapy choice to pair with your GLP-1
- Every protocol is overseen by board-certified doctors
Cons
- Claims that NAD+ aids weight loss aren't well supported by trials
- It's hazy about which drugs are compounded versus brand-name
Cost-minded patients curious about stacking combination therapies
Trimi: Detailed Look
Trimi
Flat-price compounded GLP-1 — your cost stays the same as your dose climbs
Pros
- Flat monthly price that doesn't change as your dose is adjusted
- Compounded semaglutide from $99/mo, tirzepatide from $125/mo
- US-licensed clinicians (via Arora Health) prescribing in all 50 states
- 100% online with medication shipped to your door
Cons
- The lowest $99/$125 pricing requires an annual plan
- Compounded medications are not FDA-approved
Self-pay patients who want a flat, predictable price as their dose increases
How to Decide Between Them
There is no single winner for everyone — it comes down to what matters most to you. Match your priority to the scenarios below to see which provider fits:
Go with Trimi at $99/month. Compounded semaglutide $99/mo and tirzepatide $125/mo on annual plans — and the price doesn't rise as your dose increases..
Enhance MD has the edge with a 8.3 rating.
Trimi focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified doctors, while Trimi provides us-licensed clinicians via arora health.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than Trimi?
Enhance MD has a 8.3 rating while Trimi has a 8.1 rating. The better choice depends on your priorities — Enhance MD is best for cost-minded patients curious about stacking combination therapies, while Trimi is best for self-pay patients who want a flat, predictable price as their dose increases.
How much does Enhance MD cost compared to Trimi?
Enhance MD starts at $249/month (semaglutide runs $249/mo and tirzepatide $379/mo, with yearly plans trimming roughly 15%), while Trimi starts at $99/month (compounded semaglutide $99/mo and tirzepatide $125/mo on annual plans — and the price doesn't rise as your dose increases.).
Do Enhance MD and Trimi accept insurance?
Enhance MD does not accept insurance. Trimi does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs Trimi?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. Trimi offers Compounded Semaglutide, Compounded Tirzepatide.
Can I cancel Enhance MD or Trimi at any time?
Enhance MD allows cancel anytime. Trimi also allows cancel anytime.
Are Enhance MD and Trimi available in my state?
Enhance MD is available in all 50 states. Trimi is available in all 50 states.
Not sure Enhance MD or Trimi is right for you?
Take our 6-question quiz and we'll point you to the program that fits your budget and goals best.