Enhance MD vs SkinnyRx: Which GLP-1 Program Is Better? (2026)
We put Enhance MD and SkinnyRx head-to-head — what you actually pay each month, which GLP-1 medications you can get, the level of clinician support, and where each one wins — so you can pick the cheaper, better-fit weight loss program in minutes.
Quick Verdict
We recommend SkinnyRx
Between these two providers, SkinnyRx is our pick for most users. It offers a higher overall rating (9.1 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for cost-minded patients curious about stacking combination therapies.
SkinnyRx scores 9.1/10 in our independent evaluation at $199/month, while Enhance MD scores 8.3/10 at $249/month. Both programs connect you with a licensed physician and deliver medication straight to your door. SkinnyRx also offers oral GLP-1 options for patients who prefer pills over injections. Each score weighs five things: safety and medical oversight (30%), pricing transparency (25%), value for money (20%), quality of clinical support (15%), and how fast you can get started (10%). We build these comparisons ourselves — no provider buys a better rating or a higher spot. Pricing checked April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | SkinnyRx |
|---|---|---|
| Monthly Price | $249 | $199 |
| Rating | 8.3 / 10 | 9.1 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | 48 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified doctors | U.S.-licensed doctors who turn around prescription reviews in 24-48 hours |
Figures show entry-level cash prices before any insurance. What you ultimately pay can change with your plan and the specific medication. Last checked April 2026.
Enhance MD: Detailed Look
Enhance MD
Doctor-directed weight management that also offers NAD+ add-ons
Pros
- Wallet-friendly way in, with pricing that begins at $115/month
- An uncommon NAD+ therapy choice to pair with your GLP-1
- Every protocol is overseen by board-certified doctors
Cons
- Claims that NAD+ aids weight loss aren't well supported by trials
- It's hazy about which drugs are compounded versus brand-name
Cost-minded patients curious about stacking combination therapies
SkinnyRx: Detailed Look
SkinnyRx
A rapidly scaling GLP-1 service offering pills, sublinguals, and shots with Affirm financing
Pros
- Take it three ways — as a shot, under the tongue, or as a tablet
- Overnight delivery is free and ships from FDA-regulated U.S. pharmacies
- Billed month to month, so you're never locked into a contract
- Thousands of verified Trustpilot reviews average a 4.8 out of 5
Cons
- You'll pay cash — they don't run anything through insurance
- Only compounded formulas here; brand-name versions aren't offered
People who want their GLP-1 in several formats — tablet, sublingual, or injection
How to Decide Between Them
There is no single winner for everyone — it comes down to what matters most to you. Match your priority to the scenarios below to see which provider fits:
Go with SkinnyRx at $199/month. Semaglutide runs $199/mo; tirzepatide climbs as high as $349/mo.
SkinnyRx has the edge with a 9.1 rating.
SkinnyRx focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified doctors, while SkinnyRx provides u.s.-licensed doctors who turn around prescription reviews in 24-48 hours.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than SkinnyRx?
Enhance MD has a 8.3 rating while SkinnyRx has a 9.1 rating. The better choice depends on your priorities — Enhance MD is best for cost-minded patients curious about stacking combination therapies, while SkinnyRx is best for people who want their glp-1 in several formats — tablet, sublingual, or injection.
How much does Enhance MD cost compared to SkinnyRx?
Enhance MD starts at $249/month (semaglutide runs $249/mo and tirzepatide $379/mo, with yearly plans trimming roughly 15%), while SkinnyRx starts at $199/month (semaglutide runs $199/mo; tirzepatide climbs as high as $349/mo).
Do Enhance MD and SkinnyRx accept insurance?
Enhance MD does not accept insurance. SkinnyRx does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs SkinnyRx?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. SkinnyRx offers Compounded Semaglutide (Injectable), Compounded Semaglutide (Sublingual), Compounded Tirzepatide (Injectable), Compounded Tirzepatide (Tablets).
Can I cancel Enhance MD or SkinnyRx at any time?
Enhance MD allows cancel anytime. SkinnyRx also allows cancel anytime.
Are Enhance MD and SkinnyRx available in my state?
Enhance MD is available in all 50 states. SkinnyRx is available in 48 states.
Not sure Enhance MD or SkinnyRx is right for you?
Take our 6-question quiz and we'll point you to the program that fits your budget and goals best.