Enhance MD vs MangoRx: Which GLP-1 Program Is Better? (2026)
We put Enhance MD and MangoRx head-to-head — what you actually pay each month, which GLP-1 medications you can get, the level of clinician support, and where each one wins — so you can pick the cheaper, better-fit weight loss program in minutes.
Quick Verdict
We recommend Enhance MD
Between these two providers, Enhance MD is our pick for most users. It offers a higher overall rating (8.3 vs 7.5), availability in all 50 states, both brand-name and compounded medication options. That said, MangoRx may be the better fit if you are looking for people who want one telehealth account that spans weight loss and men's health.
Enhance MD scores 8.3/10 in our independent evaluation at $249/month, while MangoRx scores 7.5/10 at $195/month. Both programs connect you with a licensed physician and deliver medication straight to your door. Each score weighs five things: safety and medical oversight (30%), pricing transparency (25%), value for money (20%), quality of clinical support (15%), and how fast you can get started (10%). We build these comparisons ourselves — no provider buys a better rating or a higher spot. Pricing checked April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | MangoRx |
|---|---|---|
| Monthly Price | $249 | $195 |
| Rating | 8.3 / 10 | 7.5 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | 45 states |
| Consultation Fee | Included | Free |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified doctors | Licensed U.S. physicians who stay available for continued support |
Figures show entry-level cash prices before any insurance. What you ultimately pay can change with your plan and the specific medication. Last checked April 2026.
Enhance MD: Detailed Look
Enhance MD
Doctor-directed weight management that also offers NAD+ add-ons
Pros
- Wallet-friendly way in, with pricing that begins at $115/month
- An uncommon NAD+ therapy choice to pair with your GLP-1
- Every protocol is overseen by board-certified doctors
Cons
- Claims that NAD+ aids weight loss aren't well supported by trials
- It's hazy about which drugs are compounded versus brand-name
Cost-minded patients curious about stacking combination therapies
MangoRx: Detailed Look
MangoRx
A single telehealth service spanning weight loss, men's health, and broader wellness needs
Pros
- Handles more than weight loss — ED, hair loss, and skincare too
- Every prescription is written by a licensed U.S. physician
- Shipping is free on whatever you order
- An easy online intake that skips the need for an appointment
Cons
- You won't see the full pricing until you finish the intake form
- Stocks compounded formulas only, with no brand-name versions
People who want one telehealth account that spans weight loss and men's health
How to Decide Between Them
There is no single winner for everyone — it comes down to what matters most to you. Match your priority to the scenarios below to see which provider fits:
Go with MangoRx at $195/month. A ballpark opening figure for the GLP-1 program.
Enhance MD has the edge with a 8.3 rating.
MangoRx focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified doctors, while MangoRx provides licensed u.s. physicians who stay available for continued support.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than MangoRx?
Enhance MD has a 8.3 rating while MangoRx has a 7.5 rating. The better choice depends on your priorities — Enhance MD is best for cost-minded patients curious about stacking combination therapies, while MangoRx is best for people who want one telehealth account that spans weight loss and men's health.
How much does Enhance MD cost compared to MangoRx?
Enhance MD starts at $249/month (semaglutide runs $249/mo and tirzepatide $379/mo, with yearly plans trimming roughly 15%), while MangoRx starts at $195/month (a ballpark opening figure for the glp-1 program).
Do Enhance MD and MangoRx accept insurance?
Enhance MD does not accept insurance. MangoRx does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs MangoRx?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. MangoRx offers Compounded Semaglutide, Compounded Tirzepatide.
Can I cancel Enhance MD or MangoRx at any time?
Enhance MD allows cancel anytime. MangoRx also allows cancel anytime.
Are Enhance MD and MangoRx available in my state?
Enhance MD is available in all 50 states. MangoRx is available in 45 states.
Not sure Enhance MD or MangoRx is right for you?
Take our 6-question quiz and we'll point you to the program that fits your budget and goals best.